12,247 results found
    1. Neuroscience

    Optimal compensation for neuron loss

    David GT Barrett, Sophie Denève, Christian K Machens
    Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Overall energy conversion efficiency of a photosynthetic vesicle

    Melih Sener, Johan Strumpfer ... Klaus Schulten
    The overall energy conversion efficiency is calculated for a bacterial vesicle that harvests solar energy for ATP production on the basis of an atomic-detail structural model.
    1. Structural Biology and Molecular Biophysics

    pH-dependent 11° F1FO ATP synthase sub-steps reveal insight into the FO torque generating mechanism

    Seiga Yanagisawa, Wayne D Frasch
    Single-molecule F1FO studies show mutation-dependent pKa changes of both FO half-channels, and proton translocation-dependent 11° ATP synthase-direction sub-steps, which support a Grotthuss proton transfer-dependent two-step FO torque generating mechanism.
    1. Developmental Biology
    2. Physics of Living Systems

    Theoretical tool bridging cell polarities with development of robust morphologies

    Silas Boye Nissen, Steven Rønhild ... Kim Sneppen
    Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

    Braden T Lobingier, Daniel P Nickerson ... Alexey J Merz
    Sec1/Munc18 (SM) proteins shield SNARE complexes from NSF/Sec18-mediated disassembly through cooperative binding interactions with SNARE complexes and the universal co-chaperone α-SNAP/Sec17.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Crystal structures of virus-like photosystem I complexes from the mesophilic cyanobacterium Synechocystis PCC 6803

    Yuval Mazor, Daniel Nataf ... Nathan Nelson
    The structure of the photosystem I (PSI) complex from Synechocystis is determined, and reaction center subunits engineered to resemble a viral PSI are found to promote promiscuous electron acceptor properties.
    1. Neuroscience
    2. Physics of Living Systems

    Fast deep neural correspondence for tracking and identifying neurons in C. elegans using semi-synthetic training

    Xinwei Yu, Matthew S Creamer ... Andrew M Leifer
    A deep neural network trained on semi-synthetic data learns to quickly track and identify neurons in Caenorhabditis elegans.
    1. Microbiology and Infectious Disease

    Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants

    Charlotte Majerczyk, Emily Schneider, E Peter Greenberg
    Quorum-sensing control of Burkholderia thailandensis toxin and immunity pairs serves to police quorum-sensing mutants and may represent a general strategy whereby cooperators can police mutants.
    1. Cell Biology
    2. Neuroscience

    PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons

    Claire E Richardson, Kerri A Spilker ... Kang Shen
    The protein PTRN-1 anchors microtubules in neuronal branches to promote proper neuron morphology and function in Caenorhabditis elegans.
    1. Neuroscience

    Predicting non-linear dynamics by stable local learning in a recurrent spiking neural network

    Aditya Gilra, Wulfram Gerstner
    Recurrent neuronal networks learn to predict movement in a self-supervised way using biologically plausible learning rules.

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