2,643 results found
    1. Neuroscience

    The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception

    Andreas Strube et al.
    Key variables required for pain perception in the context of a predictive coding model are correlated with distinct oscillatory profiles.
    1. Cancer Biology
    2. Computational and Systems Biology

    shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data

    Kenichi Shimada et al.
    shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.
    1. Cell Biology
    2. Developmental Biology

    SUMO is a pervasive regulator of meiosis

    Nikhil R Bhagwat et al.
    Multi-dimensional global proteomics describes the SUMO-modified proteome during meiosis and reveals novel roles in regulating the key events of meiotic chromosome metabolism.
    1. Ecology
    2. Microbiology and Infectious Disease

    Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing

    Heidi A Arjes et al.
    Novel high-throughput co-culture assays reveal how the spatial structure of colony biofilms provides opportunities for nutrient and matrix sharing and may drive the evolution of cooperative behaviors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

    Kathryn Milne et al.
    Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    tRNA sequences can assemble into a replicator

    Alexandra Kühnlein et al.
    Rudimentary cross-catalytic replication can be established by double-hairpins of tRNA-like sequences, implying that replication and translation could have emerged along a common evolutionary trajectory.
    1. Medicine
    2. Neuroscience

    Self-blinding citizen science to explore psychedelic microdosing

    Balázs Szigeti et al.
    The anecdotally reported benefits of psychedelics microdosing can be explained by the placebo effect.
    1. Computational and Systems Biology

    Emergence and propagation of epistasis in metabolic networks

    Sergey Kryazhimskiy
    Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
    1. Microbiology and Infectious Disease

    Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

    Sara Marelli et al.
    Systematic screen of HIV-1 Vif mutants identifies synthetic and naturally occurring amino acid polymorphisms separating PPP2R5 and APOBEC3 family protein depletion and uncovers the mechanism of Vif-dependent cell cycle arrest.
    1. Developmental Biology
    2. Plant Biology

    Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis

    Michael Borg et al.
    Epigenetic reprogramming of the distinct repressive marks H3K27me3 or H3K9me2 guides the transition between the haploid and diploid life forms that encompass the life cycle of land plants.

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