40 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham et al.
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Developmental Biology

    Extensive and diverse patterns of cell death sculpt neural networks in insects

    Sinziana Pop et al.
    Developmental cell death plays a key role during insect neurogenesis and is increased in specific neuronal populations in flies that have evolved flightlessness.
    1. Neuroscience

    Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

    Hiromasa Takemura et al.
    Polarized light imaging demonstrates detailed organization of projection, callosal, longitudinal association and short association fibers in the primate visual system at micrometer-resolution.
    1. Structural Biology and Molecular Biophysics

    A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins

    Danish Khan et al.
    A new class of fungal hemoproteins is described that emphasizes the versatility of the Sec14-fold for translating binding of chemically distinct ligands to control of diverse sets of cellular activities.
    1. Neuroscience

    Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

    Hirofumi Fujita et al.
    Medial cerebellar nucleus comprises five major types of excitatory projection neurons differentially connected with specific subsets of inferior olive neurons, Purkinje cells, and somatomotor, oromotor, positional-autonomic, orienting and arousal circuits.
    1. Developmental Biology

    Intrinsic control of muscle attachment sites matching

    Alexandre Carayon et al.
    Making a link between deletion of transcription cis-regulatory elements by CrispR/Cas9, obtention of mutants with single muscle morphology defects and their impact on locomotion.
    1. Neuroscience

    Three-dimensional synaptic organization of the human hippocampal CA1 field

    Marta Montero-Crespo et al.
    Volume electron microscopy reveals the synaptic organization of the neuropil of the human hippocampal CA1 field.
    1. Neuroscience

    Vestigial auriculomotor activity indicates the direction of auditory attention in humans

    Daniel J Strauss et al.
    Recordings of ear muscles in humans show that ears attempt to pivot in the direction that requires attention.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

    Aaron M Allen et al.
    A single-cell atlas of the adult fly VNC charts the types and properties of cells for future studies of brain development and function.
    1. Neuroscience

    Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray

    Christopher E Vaaga et al.
    The mouse cerebellum regulates innate defensive neural circuitry by tonically controlling dopamine release in the periaqueductal gray, thereby modulating synaptic responses of the Chx10-positive neurons that generate freezing behavior.

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