4,509 results found
    1. Chromosomes and Gene Expression

    Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis

    Meredith A Sommars et al.
    B cell lymphoma 6 (BCL6) represses fasting gene expression by opposing peroxisome proliferator-activated receptor alpha (PPARa) activity at enhancers, and its ablation protects against steatosis by enhancing fatty acid catabolism.
    1. Cancer Biology

    The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

    Sean W Fanning et al.
    Bazedoxifene's SERD activities enable it to resist the impact of activating ESR1 mutations in breast cancer.
    1. Neuroscience

    How spatial release from masking may fail to function in a highly directional auditory system

    Norman Lee, Andrew C Mason
    The auditory periphery of Ormia ochracea does not allow for spatial release from masking.
    1. Computational and Systems Biology

    Step-to-step variations in human running reveal how humans run without falling

    Nidhi Seethapathi, Manoj Srinivasan
    Natural step-to-step variations show how human running is stabilized, underscoring the importance of center of mass control and showing how humans run without falling despite muscle noise and uneven terrain.
    1. Ecology
    2. Evolutionary Biology

    Sex-specific effects of cooperative breeding and colonial nesting on prosociality in corvids

    Lisa Horn et al.
    A systematic experimental comparison of prosocial behavior in eight corvid species reveals sex-specific effects of cooperative breeding and colonial nesting, thereby adding important new insights regarding the evolution of prosociality.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating

    Rupamanjari Majumder et al.
    Customization of ion channel gating enhances homeostatic regulation through automatic detection and correction of abnormal physiological changes, as illustrated by self-restoration of excitation rhythm in cardiac arrhythmias.
    1. Evolutionary Biology
    2. Neuroscience

    A novel lineage of candidate pheromone receptors for sex communication in moths

    Lucie Bastin-Héline et al.
    In moths, male receptors tuned to type I female pheromones may not have a monophyletic origin.
    1. Neuroscience

    Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans

    Ignacio Rebollo et al.
    Coupling between the gastric rhythm and brain activity at rest reveals a novel resting-state network, characterized by delayed functional connectivity.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution of asymmetric gamete signaling and suppressed recombination at the mating type locus

    Zena Hadjivasiliou, Andrew Pomiankowski
    Selection for asymmetric signalling between gametes explains the very origins of sexual asymmetry as seen in mating-types with morphologically similar but self-incompatible gametes.
    1. Structural Biology and Molecular Biophysics

    Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

    Tatsuro Maruyama et al.
    Nuclear magnetic resonance analysis revealed the structural and dynamical changes in MgtE during the channel closure caused by the cooperative Mg2+-binding, which had remained undescribed only by a static crystal structure.

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