Molecular and cell biology analyses reveal novel roles of Polo-like kinases in establishing non-random segregation patterns of spindle-associated microtubule-organizing centers during mitosis, a phenomenon linked with replicative cell aging.

The polarized orientation of the mitotic spindle in budding yeast arises from spindle pole structural and functional asymmetry subject to cell cycle control.

Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.

A quantitative live imaging approach unveils that earliest neurogenic progenitors in the vertebrate retina arise from asymmetric divisions and that this asymmetry involves Notch signalling through the endocytic pathway.

A separation-of-function mutation reveals that a niche ligand receptor Dome functions in spindle orientation during asymmetric stem cell division by directly binding to Eb1, independent of its role in downstream JAK-STAT signaling.

Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.

Microtubule-depolymerizing kinesin, Klp10A, prevents overgrowth of the mother centrosome to prevent undesirable asymmetries during asymmetric divisions of Drosophila male germline stem cells.

Stem cell self-renewal strategies fall into two classes, and only strategies of different classes can be experimentally distinguished via static clonal data.

The actomyosin network and phospho-regulation combine to polarize fate determinants at the Drosophila neuroblast cell cortex.

The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.