2,444 results found
    1. Human Biology and Medicine

    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

    Naga Suresh Adapala et al.
    Site-specific modification of NEMO facilitates RANKL signal specificity in myeloid progenitors and serves as a potential target to modulate inflammatory osteolysis through ISG15-dependent autophagy.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray et al.
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Human Biology and Medicine

    High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss

    Ok-Hee Kim et al.
    A high-phytate-low Ca2+ diet causes crystal nephropathies, renal phosphate wasting, and bone disease in rats, whereas high Ca2+ intake ameliorates the detrimental effects of a high-phytate diet.
    1. Ecology
    2. Neuroscience

    The social life of Norway rats (Rattus norvegicus)

    Manon K Schweinfurth
    Rats are highly social animals that show complex social skills, which has not been acknowledged enough when controlling them in the wild and conducting research in the laboratory.
    1. Plant Biology

    UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2

    Hannes Vanhaeren et al.
    By inactivating DA1, DAR1 and DAR2 through deubiquitination, UBP12 and UBP13 regulate leaf growth, cell area and endoreduplication.
    1. Cell Biology
    2. Computational and Systems Biology

    Deciphering anomalous heterogeneous intracellular transport with neural networks

    Daniel Han et al.
    Direct estimation of the Hurst exponent shows that endosomes and lysosomes reside in regimes of persistent and anti-persistent motion with heavy-tailed residence time distributions and motion correlated with endocytic function.
    1. Neuroscience

    Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input

    Zohre Azimi et al.
    Serotonergic input to visual cortex controls ongoing and evoked activity in a separable manner via distinct receptor pathways.
    1. Evolutionary Biology

    The skin microbiome facilitates adaptive tetrodotoxin production in poisonous newts

    Patric M Vaelli et al.
    Skin-associated bacteria underlie the production of a potent defensive neurotoxin in newts, impacting host physiology, molecular evolution, and predator-prey interactions in a coevolutionary arms race.
    1. Cell Biology

    A protein quality control pathway at the mitochondrial outer membrane

    Meredith B Metzger et al.
    Temperature-sensitive mitochondrial outer membrane proteins used as novel quality control substrates reveal a unique mitochondria-associated degradation pathway consisting of both cytosolic and mitochondrial ubiquitin-proteasome system machinery.
    1. Cell Biology
    2. Developmental Biology

    Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

    Moran Cohen-Berkman et al.
    Endo-siRNAs slow down the rate of aging and enable the maintenance of a responsive heat shock response in aging germline-less Caenorhabditis elegans.

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