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488 results found
    1. Neuroscience

    The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm

    Thomas Michael Ernst et al.
    Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.
    1. Neuroscience

    Shifting from fear to safety through deconditioning-update

    Bruno Popik et al.
    Deconditioning is a safe and efficient new approach to updating traumatic memories, in which fear memory is rewritten to a very low level in a long-lasting way.
    1. Neuroscience

    Sexually divergent expression of active and passive conditioned fear responses in rats

    Tina M Gruene et al.
    Female, but not male rats exhibit an active conditioned fear response, which challenges traditional approaches to measuring fear learning exclusively through freezing, and suggests that females use a more diverse set of threat strategies.
    1. Neuroscience

    Navigating the garden of forking paths for data exclusions in fear conditioning research

    Tina B Lonsdorf et al.
    Exclusion of participants in tasks with a learning element can introduce substantial bias and needs to be carefully considered and transparently reported and justified.
    1. Neuroscience

    Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress

    Ran Inoue et al.
    Behavioral analyses and an optogenetic approach reveal an existence of GR-mediated metaplasticity in the LA and its link with adaptive fear response to auditory cues in a stressful condition.
    1. Cell Biology

    A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

    Rebecca S Mathew et al.
    A fear conditioning-induced miRNA acts in a negative feedback loop that targets vesicle exocytosis and neurotransmitter receptor trafficking, and inhibits memory formation.
    1. Neuroscience

    The integration of Gaussian noise by long-range amygdala inputs in frontal circuit promotes fear learning in mice

    Mattia Aime et al.
    The frontal associative cortex promotes fear learning by non-linearly integrating Gaussian noise in between conditioning trials with the help of basolateral amygdala inputs.
    1. Neuroscience

    Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes

    Ximena I Salinas-Hern√°ndez et al.
    Dopamine signaling is necessary for normal fear extinction learning.
    1. Neuroscience

    Instructed knowledge shapes feedback-driven aversive learning in striatum and orbitofrontal cortex, but not the amygdala

    Lauren Y Atlas et al.
    While the striatum and orbitofrontal cortex learn about threats through verbal warnings, the amygdala learns only from direct experience, suggesting that the amygdala forms part of a specialized threat detection system.
    1. Neuroscience

    Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

    Travis D Goode et al.
    The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.

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