522 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas, Neil P Blackledge ... Robert J Klose
    A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
    1. Neuroscience

    Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

    Wei Deng, Mark Mayford, Fred H Gage
    By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
    1. Plant Biology

    Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

    Katherine Noelani Chang, Shan Zhong ... Joseph R Ecker
    The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.
    1. Developmental Biology

    Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

    Ainhoa Pérez-Garijo, Yaron Fuchs, Hermann Steller
    A common mechanism might regulate the communal death of cells in flies and mammals.
    1. Immunology and Inflammation

    T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

    Karen E Tkach, Debashis Barik ... Grégoire Altan-Bonnet
    Experiment-driven quantitative model of IL-2 secretion demonstrates how T cells integrate their digital antigen responses into an analog-scaled output.
    1. Neuroscience

    Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron

    Frederic A Roemschied, Monika JB Eberhard ... Susanne Schreiber
    The firing rates of neurons in the grasshopper auditory system are surprisingly robust to changes in temperature, and cell-intrinsic mechanisms are sufficient to explain this temperature insensitivity.
    1. Neuroscience

    Neuronal connectome of a sensory-motor circuit for visual navigation

    Nadine Randel, Albina Asadulina ... Gáspár Jékely
    Three-dimensional mapping of the neural circuitry that controls movement of a marine worm in response to light provides insights into the evolution of complex visual systems.
    1. Immunology and Inflammation

    B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk

    Kathrin Kläsener, Palash C Maity ... Michael Reth
    Studying the earliest events in B cell activation reveals that the B cell antigen receptor is opened and activated via the phosphorylation and binding by the spleen tyrosine kinase (Syk).
    1. Neuroscience

    The inhibitory microcircuit of the substantia nigra provides feedback gain control of the basal ganglia output

    Jennifer Brown, Wei-Xing Pan, Joshua Tate Dudman
    Negative feedback signals within the substantia nigra regulate the output of the basal ganglia, with implications for disorders such as Parkinson's disease.
    1. Biochemistry and Chemical Biology

    Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

    Alexander A Shestov, Xiaojing Liu ... Jason W Locasale
    A new computational model of the Warburg Effect reveals that the rate-limiting step of glycolysis is variable, identifies new control mechanisms, and could help to predict the responses to targeting glycolysis to treat cancer.

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