Live cell imaging demonstrates that the dynamics of ligand presentation influence signaling through two closely related morphogen signaling pathways in dramatically different ways.
A newly identified pattern of circuit assembly shows connectivity between small groups of neurons born in tight time windows from different stem cells, with outputs from one lineage born before inputs from other lineages.
The signaling requirements to decouple proliferation of pancreatic progenitors from differentiation were elucidated and employed for the reproducible expansion, under GMP-compliant conditions, of pancreatic progenitors derived from different human pluripotent stem cell lines.
Crystal Rock, Hector Zurita ... Alfonso junior Apicella
The discovery of somatostatin-positive inhibitory neurons projecting from mouse cortex to striatum shows that corticostriatal pathways are not exclusively excitatory.
Ariel Ogran, Tal Havkin-Solomon ... Rivka Dikstein
Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
The first postnatal week ends with the development of perisomatic innervation and with an abrupt switch in the representation of self-motion in the region CA1 of the mouse hippocampus.
Merve Deniz Abdusselamoglu, Elif Eroglu ... Jürgen A Knoblich
Odd-paired (opa) is required for the progression of temporal patterning in Drosophila neural progenitors to regulate temporal identities via an incoherent feed-forward loop.
Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
