Giulio Bondanelli, Thomas Deneux ... Srdjan Ostojic
Computational modeling demonstrates that population dynamics of neural calcium activity following stimulus offset are consistent with a network mechanism based on recurrent interactions.
Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
Jérôme Dockès, Russell A Poldrack ... Gaël Varoquaux
Full-text analysis of the human brain-imaging literature can predict the spatial distribution of observations in the brain given the description of a subject of study.
Strong reduction in malaria transmission by genetically modified mosquitoes is achieved in the laboratory using a dual gene drive that simultaneously propagates an antiparasitic factor and a parasite-detrimental mosquito mutation.
Christopher P Arnold, M Shane Merryman ... Alejandro Sánchez Alvarado
An innate immune system signaling pathway in planarians has a dual role: it enhances apoptosis during bacterial infection, but represses apoptosis during tissue regeneration in the absence of infection.
Ellen KW Brennan, Izabela Jedrasiak-Cape ... Omar J Ahmed
Parallel input streams to layer 1 identify a computationally distinct principal neuronal subtype ideally positioned to support spatial orientation computations in the granular retrosplenial cortex.