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Electron microcopy-based connectomics, in vivo functional imaging, and biophysical modeling reveal that mouse visual cortex chandelier cells, a type of GABAergic interneuron, are driven by arousal and distribute their synapses according to the individual properties of target cells.

Morphological profiling of untreated HCT116 cells using Cell Painting reveals a signature of bortezomib resistance, providing a proof-of-concept for the unbiased analysis of drug resistance.

Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.

The finding that deletion of the genome folding motor leaves a significant fraction of a key structural feature of chromosome at the single cell and ensemble level has been explained.

The detection of low quantities of alkaloids in putatively nontoxic species of poison frogs sheds light on early evolutionary stages of chemical defense in animals.

Experimental manipulations of social groups of ostriches show that the benefits of cooperative parental care for females, and the costs of sexual competition for males, lead to sex differences in optimal group sizes.

In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..

When crowded bacterial colonies invade a closed area, flow-induced alignment creates strong radial orientation and leads to the formation of aster defects.

Morphologically-mature granule cells with complex dendritic trees contribute to a sparse representation of space in the rat dentate gyrus.

Computational methods reveal how mutations affect the conformational landscape of the kinase domain of EGFR resulting in abnormal signaling and provide a structural framework for ongoing drug discovery efforts on mutant-specific EGFR inhibition.