3,309 results found
    1. Cell Biology

    Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

    Szymon Juszkiewicz, Greg Slodkowicz ... Ramanujan S Hegde
    Ribosome collisions along an mRNA are shown to recruit factors that prevent additional ribosomes from initiating translation on that mRNA, thereby providing time to resolve the collision.
    1. Developmental Biology

    Nodal patterning without Lefty inhibitory feedback is functional but fragile

    Katherine W Rogers, Nathan D Lord ... Alexander F Schier
    Lefty-mediated feedback inhibition of Nodal signaling mitigates signaling perturbations, but is dispensable for development.
    1. Neuroscience

    Quantitative properties of a feedback circuit predict frequency-dependent pattern separation

    Oliver Braganza, Daniel Mueller-Komorowska ... Heinz Beck
    The feedback inhibitory microcircuit of the dentate gyrus likely boosts pattern separation during gamma oscillations.
    1. Neuroscience

    Feedback inhibition underlies new computational functions of cerebellar interneurons

    Hunter E Halverson, Jinsook Kim ... George J Augustine
    An inhibitory feedback circuit from Purkinje cells to molecular layer interneurons within the cerebellum has been characterized and found to be employed in vivo during motor learning.
    1. Neuroscience

    Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex

    Nathaniel J Miska, Leonidas MA Richter ... Gina G Turrigiano
    Sensory deprivation suppresses cortical responsiveness through a selective remodeling of excitatory and inhibitory microcircuit motifs, by simultaneously amplifying feedforward and suppressing feedback excitation.
    1. Neuroscience

    A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields

    Luca Cocchi, Martin V Sale ... Jason B Mattingley
    The selective effect of local inhibition on diffuse patterns of brain connectivity can be accounted for by an intrinsic hierarchical ordering of cortical timescales.
    1. Neuroscience

    Feedback inhibition by a descending GABAergic neuron regulates timing of escape behavior in Drosophila larvae

    Jiayi Zhu, Jean-Christophe Boivin ... Tomoko Ohyama
    Connectomic, optogenetic, and high-throughput behavioral analyses identify a descending neuron in the fruit fly larval brain that modifies the timing of nociception-induced rolling.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray, Zane N Aldworth, Mark A Stopfer
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Neuroscience

    Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel

    Seika Takayanagi-Kiya, Keming Zhou, Yishi Jin
    An anion-selective ligand gated channel acts as a presynaptic auto-receptor to modulate vesicle release and neuronal excitation.
    1. Computational and Systems Biology
    2. Developmental Biology

    A balance of positive and negative regulators determines the pace of the segmentation clock

    Guy Wiedermann, Robert Alexander Bone ... J Kim Dale
    Computational modelling together with experimental manipulation indicate that the stability and turnover of activated Notch is inextricably linked to the regulation of the pace of segmentation clock gene expression in the presomitic mesoderm.

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