Szymon Juszkiewicz, Greg Slodkowicz ... Ramanujan S Hegde
Ribosome collisions along an mRNA are shown to recruit factors that prevent additional ribosomes from initiating translation on that mRNA, thereby providing time to resolve the collision.
Hunter E Halverson, Jinsook Kim ... George J Augustine
An inhibitory feedback circuit from Purkinje cells to molecular layer interneurons within the cerebellum has been characterized and found to be employed in vivo during motor learning.
Nathaniel J Miska, Leonidas MA Richter ... Gina G Turrigiano
Sensory deprivation suppresses cortical responsiveness through a selective remodeling of excitatory and inhibitory microcircuit motifs, by simultaneously amplifying feedforward and suppressing feedback excitation.
The selective effect of local inhibition on diffuse patterns of brain connectivity can be accounted for by an intrinsic hierarchical ordering of cortical timescales.
Connectomic, optogenetic, and high-throughput behavioral analyses identify a descending neuron in the fruit fly larval brain that modifies the timing of nociception-induced rolling.
Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
Guy Wiedermann, Robert Alexander Bone ... J Kim Dale
Computational modelling together with experimental manipulation indicate that the stability and turnover of activated Notch is inextricably linked to the regulation of the pace of segmentation clock gene expression in the presomitic mesoderm.