1,465 results found
    1. Developmental Biology

    Nodal patterning without Lefty inhibitory feedback is functional but fragile

    Katherine W Rogers et al.
    Lefty-mediated feedback inhibition of Nodal signaling mitigates signaling perturbations, but is dispensable for development.
    1. Neuroscience

    Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex

    Nathaniel J Miska et al.
    Sensory deprivation suppresses cortical responsiveness through a selective remodeling of excitatory and inhibitory microcircuit motifs, by simultaneously amplifying feedforward and suppressing feedback excitation.
    1. Neuroscience

    Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel

    Seika Takayanagi-Kiya et al.
    An anion-selective ligand gated channel acts as a presynaptic auto-receptor to modulate vesicle release and neuronal excitation.
    1. Cell Biology

    Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

    Szymon Juszkiewicz et al.
    Ribosome collisions along an mRNA are shown to recruit factors that prevent additional ribosomes from initiating translation on that mRNA, thereby providing time to resolve the collision.
    1. Neuroscience

    Feedback inhibition and its control in an insect olfactory circuit

    Subhasis Ray et al.
    Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
    1. Neuroscience

    Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition

    Kevin M Collins et al.
    The neural circuit that regulates egg-laying behavior in nematode worms is activated by egg production, coupled to the circuit that generates movement, and inhibited by sensory feedback from egg release.
    1. Cancer Biology

    Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells

    Arun M Unni et al.
    Cancer cells driven by mutations in KRAS or EGFR are dependent on DUSP6 to prevent ERK-induced cell death, creating a novel vulnerability for targeted therapy.
    1. Neuroscience

    Quantitative properties of a feedback circuit predict frequency-dependent pattern separation

    Oliver Braganza et al.
    The feedback inhibitory microcircuit of the dentate gyrus likely boosts pattern separation during gamma oscillations.
    1. Neuroscience

    Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network

    Sam A Booker et al.
    Presynaptic GABAB receptors are highly expressed and strongly suppress synaptic transmission at the input and output of hippocampal somatostatin interneurons.
    1. Cell Biology
    2. Plant Biology

    The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase

    Andreas S Richter et al.
    Heme-dependent feedback inhibition of rate-limiting ALA-synthesis of plant tetrapyrrole biosynthesis depends on binding of heme to glutamyl-tRNA reductase-binding protein.

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