Clytia jellyfish regenerate body shape and organs through a mechanically driven process that coordinates tissue remodeling, localized proliferation, and precursor migration and promotes Wnt signaling at a muscle-based landmark.
Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
Whisker barrels provide clues about neocortical development, as computer modelling shows that barrels can self-organize, based on competition between adjacent thalamocortical axons, suggesting that genetic instruction plays a secondary role.
Whether central vestibular neurons implement faithful stimulus encoding for the vestibulo-occular reflex or optimized coding via temporal whitening for other vestibular functions is determined by neural variability.
SOX11+ breast tumours display reactivated embryonic developmental signalling and organogenetic features and are at elevated risk of developing metastases, so may benefit from more aggressive therapies.