A 'male-harming' mtDNA mutation has been identified in Drosophila and impairs male fertility without impairing other male or female functions.

Single-cell RNA sequencing of neonatal uterus revealed an Misr2+ endometrial stromal progenitor whose inhibition by ectopic administration of MIS caused uterine hypoplasia and infertility in adulthood.

A chronic stressor prior to mating has lasting negative consequences on the fertility and fecundity of female rats, which can be prevented by blocking a single hypothalamic reproductive inhibitory hormone.

Spermatozoa require GIV for specialized compartmentalized signaling to support efficient capacitation while inhibiting premature acrosome reaction.

Rapid acquisition of chromosome rearrangements, together with independently acting transmission distorter alleles on each chromosome, drive near complete sterility in fission yeast hybrids.

ADGRG2, an orphan GPCR, when coupled to CFTR via a regional Gq signaling on the apical membrane, acts to regulate efferent duct fluid reabsorption making it essential for male fertility.

High reproductive effort constrains bone tissue response to physical activity-induced mechanical loading.

HIPK4 is a male germ cell-enriched kinase that regulates cytoskeletal rearrangements in spermatids during spermiogenesis and is required for male fertility in mice.

Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.

Mitochondrial genomes harbor male-fertility-reducing mutations that can be harnessed to control population viability as a novel approach to control economic and environmental pests.