102 results found
    1. Cell Biology
    2. Developmental Biology

    The interplay of stiffness and force anisotropies drives embryo elongation

    Thanh Thi Kim Vuong-Brender, Martine Ben Amar ... Michel Labouesse
    Elongation of C. elegans embryos requires stiffness and force to be specifically oriented in a coordinated manner in different cells.
    1. Neuroscience

    Cerebellar learning using perturbations

    Guy Bouvier, Johnatan Aljadeff ... Boris Barbour
    A proposal for a complete cellular/network implementation of trial-and-error motor learning in the olivo-cerebellar system.
    1. Cell Biology

    PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

    Shuxian Li, Lingbing Li ... Xietong Wang
    Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.
    1. Neuroscience

    The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement

    Kara K Cover, Abby G Lieberman ... Brian N Mathur
    Neural circuit monitoring and manipulation reveal that neurons of the rostral intralaminar nuclei of the thalamus projecting to the dorsal striatum activate at movement initiation and reward to reinforce actions.
    1. Neuroscience

    Precisely timed dopamine signals establish distinct kinematic representations of skilled movements

    Alexandra Bova, Matt Gaidica ... Daniel K Leventhal
    Dopamine signaling gradually causes long-lasting changes in fine motor coordination that can later be activated by acute changes in dopamine neuron activity.
    1. Computational and Systems Biology
    2. Medicine

    Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

    Savannah F Bifulco, Griffin D Scott ... Patrick M Boyle
    In models reconstructed from MRI scans of patients with embolic stroke of undetermined source, computational simulations reveal that fibrosis has the intrinsic capacity to sustain arrhythmia drivers when subjected to triggered activity known to exist in patients with atrial fibrillation.
    1. Neuroscience

    Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Mingzheng Wu, Samuel Minkowicz ... Yevgenia Kozorovitskiy
    Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
    1. Neuroscience

    nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice

    Christina T Echagarruga, Kyle W Gheres ... Patrick J Drew
    The diameter of cortical arteries is not controlled by the overall neural activity, but rather by a subset of specialized neurons.
    1. Neuroscience

    An open-source platform for head-fixed operant and consummatory behavior

    Adam Gordon-Fennell, Joumana M Barbakh ... Garret D Stuber
    A customizable open-source hardware and software platform for conducting diverse behavioral experiments in head-fixed mice.
    1. Cell Biology
    2. Physics of Living Systems

    Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

    Pooja Suresh, Alexandra F Long, Sophie Dumont
    Directly exerting force on the mammalian spindle reveals local and short-lived reinforcement in the spindle center, well-suited to preserve connections to chromosomes over seconds and yet allow remodeling over minutes.

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