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    1. Cell Biology

    circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

    Minmin Song et al.
    Upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium sponged miR-21–5 p and resulted in upregulation of its target gene, ΔNp63α, which induced transition of EECs to mesenchymal cells.
    1. Stem Cells and Regenerative Medicine

    Cell non-autonomous functions of S100a4 drive fibrotic tendon healing

    Jessica E Ackerman et al.
    Inhibition of S100a4 represents a novel anti-fibrotic target to improve tendon healing.
    1. Computational and Systems Biology

    Unravelling druggable signalling networks that control F508del-CFTR proteostasis

    Ramanath Narayana Hegde et al.
    Analysis of the mechanism of action of cystic fibrosis corrector drugs reveals signalling pathways potently controlling the proteostasis of the main disease-relevant CFTR mutant.
    1. Cell Biology
    2. Immunology and Inflammation

    Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes

    Yiran Zang et al.
    Excess membrane can trap outgoing extracellular matrix proteins in secreting cells, leading to pericellular deposits that cause tissue damage.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Developmental Biology

    A structure-based extracellular matrix expansion mechanism of fibrous tissue growth

    Nicholas S Kalson et al.
    Tendon fibroblast cells lay down a collagen matrix template during embryogenesis, and the expansion of this matrix drives post-natal tissue growth.
    1. Cell Biology

    Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

    Chelsea Hepler et al.
    Fibro-inflammatory progenitors represent a subpopulation of perivascular cells in visceral adipose tissues of mice that promote inflammation and fibrosis.
    1. Cell Biology
    2. Medicine

    Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

    LouJin Song et al.
    Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.
    1. Microbiology and Infectious Disease

    Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa

    Dominique H Limoli et al.
    Pseudomonas aeruginosa coordinates invasion and destruction of Staphylococcus aureus communities by modulating single-cell and collective motility.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization

    Csaba Mihályi et al.
    Coupling of CFTR pore opening to nucleotide binding domain dimerization does not depend on ATP binding, but is an inherent property of the channel protein and likely other ABC transporters.