The formation of HIV-1 particles requires a bending of the membrane that cannot be achieved by the Gag protein alone and thus there is need for the I-BAR protein IRSp53 to aid in the formation of HIV-1 buds.
Manuel Alonso Y Adell, Simona M Migliano ... David Teis
Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.
A novel mathematical strategy for the integrated analysis of adult body structures quantifies the degree and nature of developmental robustness and its evolutionary implications.
Maaike Welling, Manuel Alexander Mohr ... Periklis Pantazis
Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.
Following anterior temporal lobe neurodegeneration, defective semantic representations are compensated via enhanced perceptual processing and associated with a dysregulation of the semantic control system.
Michael J Currie, James S Davies ... Rachel A North
Structure of the dimeric Haemophilus influenzae TRAP transporter (SiaQM) reveals two Na+ sites, the substrate-binding site and lipid-binding sites, and weak but promiscuous binding of SiaP to SiaQM.
The Ran GTPase plays a role in defining the physical properties of the nuclear pore complex transport channel by remodeling the binding interactions of importin-β with the nucleoporin Nup153 at the nuclear face of the pore.
Direct observation in the developing fly brain indicates that the response of a growth cone in a gradient of a guidance cue is adhesion to the source of the cue rather than attraction by the gradient.
