Elevated growth differentiation factor-15 (GDF15) levels do not appear to be a causal factor in body mass index (BMI) in humans but higher BMI does cause increases in GDF15.

eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of the immune response to cancer cells.

The extinct stilt-legged equids of North America are not related to Asiatic asses or horses, but instead represent a distinct lineage outside of living equid diversity that became extinct in the terminal Pleistocene.

Our latest Special Issue brings together research on the allosteric regulation of kinase activity.

Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.

First evidence of cohesin folding occurring in vivo and during cohesion together with a detailed description of the structural aspects of cohesin's elbow folding through a series of novel structures.

eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of microbiome function.

Boundary:boundary pairing interactions drive TAD formation in Drosophila.

Task controllability manipulations reveal that information seeking is associated with reduced confidence and active hypothesis testing, as well as stronger neurophysiological correlates of attention and arousal.

Synaptic modulations alone imbue networks with computational capabilities comparable to recurrent connections on several neuroscience-relevant tasks, which manifest in fundamentally different neuronal dynamics.