707 results found
    1. Plant Biology
    2. Evolutionary Biology

    Herbivory-induced volatiles function as defenses increasing fitness of the native plant Nicotiana attenuata in nature

    Meredith C Schuman, Kathleen Barthel, Ian T Baldwin
    A 2-year field study has demonstrated that volatile compounds produced by plants when they are attacked by herbivores act as defenses by attracting predators to the herbivores and increasing the reproduction of the plants.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri, Gabriel C Lander ... Eva Nogales
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Structural Biology and Molecular Biophysics

    Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

    Chunguang Kong, Weizhong Zeng ... Youxing Jiang
    Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.
    1. Cell Biology

    Time line of redox events in aging postmitotic cells

    Nicolas Brandes, Heather Tienson ... Ursula Jakob
    A sudden fall in the levels of the coenzyme NADPH within cells could have a central role in the process of aging.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Mechanism for priming DNA synthesis by yeast DNA Polymerase α

    Rajika L Perera, Rubben Torella ... Luca Pellegrini
    The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.
    1. Neuroscience

    Decoding the neural mechanisms of human tool use

    Jason P Gallivan, D Adam McLean ... Jody C Culham
    Imaging experiments reveal that some brain regions do not distinguish between actions performed using tools and those performed using the hands, while others represent these two types of action separately.
    1. Neuroscience

    Skill learning strengthens cortical representations of motor sequences

    Tobias Wiestler, Jörn Diedrichsen
    Detailed analysis of fMRI data shows that sequences of movements are associated with individual patterns of neural activity that become more distinct with training.
    1. Cell Biology
    2. Immunology and Inflammation

    MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

    Siqi Liu, Jueqi Chen ... Zhijian J Chen
    A cell-free system combined with cell-based assays elucidate the biochemical mechanism of signal transduction mediated by the mitochondrial protein MAVS and delineates the role of ubiquitin E3 ligases in antiviral innate immune responses.
    1. Structural Biology and Molecular Biophysics

    Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

    Manchuta Dangkulwanich, Toyotaka Ishibashi ... Carlos J Bustamante
    Quantification of all the major on- and off-pathway kinetic parameters in the transcription elongation cycle reveals that RNA polymerase II translocates slowly in a linear, non-branched Brownian ratchet mechanism.
    1. Neuroscience

    Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics

    Keming Zhou, Tamara M Stawicki ... Yishi Jin
    The precise position of UNC-13 at the active zone near a synapse depends on the N-terminus of the protein, and the C2A domain in particular, and is essential for accelerating neurotransmitter release.

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