Motor fatigability is associated with a decrease in inhibition throughout the motor network, suggesting that selective inhibitory control is a key mechanism to maintain motor efficiency during repetitive movements.
Neural populations in PPC dynamically represent motor-like and then sensory-like aspects of brain–computer interface finger movements with a representational structure that matches able-bodied individuals.
Lisa Baumgartner, Dominik Handler ... Julius Brennecke
Kipferl, a ZAD zinc finger protein from Drosophila, determines the chromatin binding specificity of the heterochromatin protein variant Rhino, defining piRNA clusters and preventing Rhino sequestration by selfish Satellite repeats.
Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke
Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.
Brian A Sosa, F Esra Demircioglu ... Thomas U Schwartz
LAP1 adopts an AAA+ like fold that, while unable to bind nucleotide, can enhance ATPase activity in the neighboring TorsinA protomer in an unusual heterohexameric ring, via an arginine finger.
The 24 ankyrin repeats of ankyrin proteins form an extended solenoid that provides an extremely conserved groove for binding to numerous targets via combinatorial usage of multiple weak interaction sites.
Kelsie M Rodriguez, Sara C Buch-Larsen ... Michael S Cohen
A combined chemical genetics, proximity labeling, and ADP-ribose site mapping approach shows that PARP-7 mono-ADP-ribosylates immune-relevant proteins on cysteine amino acids.
Conventional annotations of coding sequences have missed thousands of short open-reading frames encoding proteins that are conserved and with specific functions.
