1,982 results found
    1. Physics of Living Systems

    Hydrodynamic model of fish orientation in a channel flow

    Maurizio Porfiri, Peng Zhang, Sean D Peterson
    A hydrodynamic model of fish swimming in a channel predicts a critical flow speed for fish to successfully swim against a flow, unveiling a passive mechanism for rheotaxis to emerge without access to any sensory information.
    1. Computational and Systems Biology
    2. Neuroscience

    From behavior to circuit modeling of light-seeking navigation in zebrafish larvae

    Sophia Karpenko, Sebastien Wolf ... Georges Debrégeas
    Light-seeking strategies in Zebrafish larvae are dissected using a virtual-reality assay, and these data are used to establish minimal stochastic and neural-circuits models that quantitatively capture this behavior.
    1. Ecology
    2. Evolutionary Biology

    Multiple preferred escape trajectories are explained by a geometric model incorporating prey’s turn and predator attack endpoint

    Yuuki Kawabata, Hideyuki Akada ... Paolo Domenici
    The mathematical model incorporating new parameters explains multimodal distributions in escape direction (i.e., multiple preferred escape trajectories), which are previously observed in various animal taxa.
    1. Neuroscience
    2. Physics of Living Systems

    Variability in locomotor dynamics reveals the critical role of feedback in task control

    Ismail Uyanik, Shahin Sefati ... Noah J Cowan
    Animals rely on sensory feedback rather than the precise tuning in the nervous system to achieve robust behavioral performances.
    1. Cell Biology
    2. Developmental Biology

    zGrad is a nanobody-based degron system that inactivates proteins in zebrafish

    Naoya Yamaguchi, Tugba Colak-Champollion, Holger Knaut
    The F-box/anti-GFP nanobody fusion protein zGrad depletes GFP-tagged proteins with spatial and temporal control in zebrafish.
    1. Biochemistry and Chemical Biology

    Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

    Peter Ahorukomeye, Maria M Disotuar ... Helena Safavi-Hemami
    The unique modus operandi of cone snail venom insulins provides new insight into insulin receptor activation and informs on the design of insulin analogs for the treatment of diabetes.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

    Beth M Stadtmueller, Kathryn E Huey-Tubman ... Pamela J Bjorkman
    The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Social interactions drive efficient foraging and income equality in groups of fish

    Roy Harpaz, Elad Schneidman
    Analysis and modeling of group behavior of adult zebrafish shows that a specialized social interaction mechanism increases foraging efficiency and equality within groups, under a variety of environmental conditions.
    1. Neuroscience

    Generalization of learned responses in the mormyrid electrosensory lobe

    Conor Dempsey, LF Abbott, Nathaniel B Sawtell
    In vivo recordings and computational modeling of the electrosensory lobe of mormyrid fish provide a circuit-level description of how learning generalizes to new situations.
    1. Neuroscience

    Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

    Hadeel Alyenbaawi, Richard Kanyo ... W Ted Allison
    A traumatic brain injury model is invented for larval zebrafish and applied to a new fluorescent 'tauopathy reporter fish', revealing a role for seizures in progression towards dementias.

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