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Timing mechanism of sexually dimorphic nervous system differentiation
Laura Pereira et al.
The timing of sexual differentiation in the brain of the nematode
is controlled by a phylogenetically conserved pathway of gene regulatory factors.
Stem Cells and Regenerative Medicine
Human Biology and Medicine
Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids
Marko Z Nikolić et al.
Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
Chromosomes and Gene Expression
Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast
Wahid A Mulla et al.
Genetic analyses reveal that purely quantitative changes in the relative copy number of chromosomes can be sufficient to disrupt the epigenetic mechanisms that define the cells' differentiated state.
Essential role for SUN5 in anchoring sperm head to the tail
Yongliang Shang et al.
SUN5 is essential for the tight junction between sperm head and the head-tail coupling apparatus, and is the main cause of human acephalic spermatozoa syndrome.
Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance
Fatih Semerci et al.
In adult mouse hippocampus, neural stem cell and their progeny communicate via Lunatic Fringe mediated Notch signaling to regulate stem cell quiescence, division, and fate.
expressing cells ingress into the otic epithelium and instruct neuronal specification
Esteban Hoijman et al.
Quantitative 4D image analysis identifies a group of cells which enter into the otic primordium during morphogenesis and instructs neuronal specification.
MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders
Adam J Harrington et al.
Mice that lack the autism- and schizophrenia-linked gene
in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
Human Biology and Medicine
Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI
Tomoki Arichi et al.
Direct measure of neural and hemodynamic activity in the developing human brain shows that the insula is a major source of transient bursting events that are critical for cortical maturation.
Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation
Yuwei Jiang et al.
The activation of beige adipocyte thermogenesis by cold temperatures and β3-adrenergic receptor agonists induce beige adipocyte formation, function and perdurance.
Selective rab11 transport and the intrinsic regenerative ability of CNS axons
Hiroaki Koseki et al.
Mature axons lose the ability to regenerate because key growth molecules are excluded through changes in vesicle transport, and restoring transport can restore regeneration.
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