979 results found
  1. Scientific Publishing: The eLife approach to peer review

    Randy Schekman et al.
    All editorial decisions at eLife are taken by working scientists in a process that emphasizes fairness, speed and transparency.
    Editorial
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    1. Chromosomes and Gene Expression

    The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability

    Lamia Wahba et al.
    When a protein involved in DNA repair malfunctions, it can anneal RNA molecules to DNA molecules, creating hybrids that increase the frequency of mutations in the DNA.
    1. Developmental Biology
    2. Genetics and Genomics

    miR-124 controls male reproductive success in Drosophila

    Ruifen Weng et al.
    A small RNA molecule called miR-124 controls pheromone production and sexual behaviour in Drosophila by regulating sex-specific gene expression in males.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    The autoregulation of a eukaryotic DNA transposon

    Corentin Claeys Bouuaert et al.
    A DNA transposon, or ‘jumping gene’, controls its amplification within a genome through a competition between the enzyme multimers that are responsible for its mobility.
    1. Genetics and Genomics

    Genomics: The early days of late blight

    Paul RJ Birch, David EL Cooke
    Insight
    Available as:
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    1. Evolutionary Biology
    2. Cancer Biology

    Evolutionary dynamics of cancer in response to targeted combination therapy

    Ivana Bozic et al.
    A study that models the evolution of drug resistance in tumors reveals that drugs are more effective when given in combination than sequentially, and that cure is much more likely when the drugs target different pathways.
  2. Point of View: A recipe for mediocrity and disaster, in five axioms

    Henry R Bourne
    Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.

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