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750 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Comprehensive fitness maps of Hsp90 show widespread environmental dependence

    Julia M Flynn et al.
    Environmental conditions strongly impact the fitness effects of Hsp90, resulting in the selection of Hsp90 sequences in nature that are robust to a variety of stressful conditions.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

    Patrick T Dolan et al.
    Distinct selective landscapes in mosquito and human cells shape dengue virus genetic diversity and highlight mechanisms of host adaptation in arboviruses.
    1. Evolutionary Biology

    Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

    Grant Kinsler et al.
    A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.
    1. Ecology
    2. Plant Biology

    Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness

    Rachel Kerwin et al.
    Environmental heterogeneity may contribute to the high levels of genetic variation in glucosinolate genes found in Arabidopsis thaliana.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells

    Raghuvir Viswanatha et al.
    Pooled CRISPR knockout screening in Drosophila cells enables high-resolution, genome-wide functional genomic comparisons in cell-lines across vast evolutionary distance.
    1. Microbiology and Infectious Disease

    Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

    Elizabeth A Mueller et al.
    Environmental specialization of bacterial cell wall synthases influences intrinsic resistance to cell wall active antibiotics.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicting mutational routes to new adaptive phenotypes

    Peter A Lind et al.
    A combination of genetics, experimental evolution and mathematical modelling defines information necessary to predict the outcome of short-term adaptive evolution.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Dengue genetic divergence generates within-serotype antigenic variation, but serotypes dominate evolutionary dynamics

    Sidney M Bell et al.
    Each dengue serotype contains moderate antigenic diversity, and population immunity drives clade turnover in a hyperendemic population.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong et al.
    Some of the mutations that occur during influenza evolution can only be tolerated in conjunction with other mutations that increase the stability of a viral protein.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Symbiont location, host fitness, and possible coadaptation in a symbiosis between social amoebae and bacteria

    Longfei Shu et al.
    Morphological and fitness defects imposed on amoebae hosts by Burkholderia symbionts demonstrates symbiont species-specific effects and provides evidence of host adaptation to naturally acquired symbionts.

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