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    1. Neuroscience

    Activity-dependent synapse clustering underlies eye-specific competition in the developing retinogeniculate system

    Chenghang Zhang, Tarlan Vatan, Colenso M Speer
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Separating the control of moving and holding in post-stroke arm paresis

    Alkis M Hadjiosif, Kahori Kita ... John W Krakauer
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

    Courtney Tindle, MacKenzie Fuller ... Soumita Das
    An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
    1. Cell Biology

    Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

    Yang Zhang, Pengfei Liang ... Huanghe Yang
    A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.
    1. Neuroscience

    Cortico-striatal action control inherent of opponent cognitive-motivational styles

    Cassandra Avila, Martin Sarter
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

    Li A Zhang, Peichao Li, Edward M Callaway
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Adaptive coding for dynamic sensory inference

    Wiktor F Młynarski, Ann M Hermundstad
    To make reliable but metabolically efficient perceptual inferences in a changing world, neural systems should dynamically adapt based on surprise and uncertainty about the sensory environment.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position

    Sean E McGeary, Namita Bisaria ... David P Bartel
    Affinity measurements of microRNA sites representing >1000 different pairing architectures reveal that two binding modes can mediate pairing to the microRNA 3′ region, and that microRNA G and oligo(G/C) residues are most impactful.
    1. Microbiology and Infectious Disease

    A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus

    Marcel Rühling, Fabio Schmelz ... Martin J Fraunholz
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Cell chirality reversal through tilted balance between polymerization of radial fibers and clockwise-swirling of transverse arcs

    Hoi Kwan Kwong, Miu Ling Lam ... Ting-Hsuan Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling