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    1. Neuroscience

    Hippocampal theta coordinates memory processing during visual exploration

    James E Kragel, Stephen VanHaerents ... Donna J Bridge
    Eye movements time-locked to retrieval and novelty during learning preferentially occur at distinct phases of hippocampal theta.
    1. Cell Biology
    2. Ecology

    Systems analysis of the CO2 concentrating mechanism in cyanobacteria

    Niall M Mangan, Michael P Brenner
    Systems level modeling of cyanobacterial mechanism for concentrating carbon dioxide shows optimal organization and enzymatic activity for enhanced carbon fixation.
    1. Cell Biology

    Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

    Julie Favre, Emilie Vessieres ... Daniel Henrion
    A new pathway is described involving the estrogen receptor alpha in the acute response of small arteries to flow independent of the ligand (estrogen) and of the nuclear signaling.
    1. Neuroscience

    Cell type specificity of neurovascular coupling in cerebral cortex

    Hana Uhlirova, Kıvılcım Kılıç ... Anna Devor
    Excitatory and inhibitory cortical neurons drive parallel vasodilatory pathways, while vasoconstriction is mediated exclusively by inhibition acting via Neuropeptide Y binding to Y1 receptors.
    1. Neuroscience

    Rapid stimulus-driven modulation of slow ocular position drifts

    Tatiana Malevich, Antimo Buonocore, Ziad M Hafed
    Slow, continuous changes in eye position when gaze is fixed, previously believed to be random drifts, are shown to exhibit highly systematic and short-latency response characteristics to visual stimuli.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Selenocyanate derived Se-incorporation into the nitrogenase Fe protein cluster

    Trixia M Buscagan, Jens T Kaiser, Douglas C Rees
    X-ray crystal structures capture ATP-dependent chalcogenide exchange from selenocyanate at the nitrogenase Fe protein cluster in the absence of the MoFe protein, an unexpected result as the Fe protein cluster is not traditionally perceived as a site of substrate binding.
    1. Biochemistry and Chemical Biology

    Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

    Maria Carmela Filomena, Daniel L Yamamoto ... Marie-Louise Bang
    Ablation of the sarcomeric protein myopalladin (MYPN), associated with human cardiomyopathies, results in dilated cardiomyopathy, which is severely aggravated by biomechanical stress, suggesting that skeletal myopathy patients carrying MYPN loss-of-function mutations may develop cardiomyopathy under conditions of cardiac stress.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes

    Benjamin D Hobson, Linghao Kong ... Peter A Sims
    Although puromycin staining is often used to examine subcellular translation, puromycin-labeled proteins are rapidly released from ribosomes even in the presence of elongation inhibitors, which may confound translation site localization.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation after a sudden change in environment

    Laura Katharine Hayward, Guy Sella
    A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans

    Donato Giovannelli, Stefan M Sievert ... Costantino Vetriani
    The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO2 fixation.