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High-throughput and ultra-stable magnetic tweezers reveal that Remdesivir induces a long-lived backtrack pause upon incorporation by the coronavirus polymerase, and SARS-CoV-2 is able to evade interferon-induced antiviral ddhCTP.

Cryo-electron tomography unveils striking new structural components of positive-strand virus RNA replication compartments, greatly advancing mechanistic insights into the structure, assembly, function and control of these critical complexes.

A masked cryo-EM image classification approach and the structure of an inhibitor-bound complex provide insights into the molecular flexibility of the catalytic subunit of gamma-secretase.

How large-scale single mosquito metatranscriptomics can define the mosquito’s complex microbiota and its blood meal sources, and contribute critical epidemiological information needed to control vector borne disease transmission, is shown.

Tick-derived sequence variation in the fusion glycoprotein of Crimean-Congo hemorrhagic fever virus (CCHFV) drastically impairs infection of mammalian cells, suggesting that certain CCHFV strains undergo purifying selection in mammalian hosts.

CLEVER enables the rapid manipulation and direct rescue of plus-strand RNA viruses with the shortest hands-on time to study viral variants of concern.

The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.

Each dengue serotype contains moderate antigenic diversity, and population immunity drives clade turnover in a hyperendemic population.

A subset of myeloid cells expressing CXCR3 is recruited to the hypothalamus and protects against the metabolic abnormalities generated in diet-induced obesity.

An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.