2,452 results found
    1. Neuroscience

    Activity patterns of serotonin neurons underlying cognitive flexibility

    Sara Matias, Eran Lottem ... Zachary F Mainen
    Recordings from serotonin-producing neurons in the brain reveal that these neurons are highly activated by sudden changes in previously familiar environments, potentially explaining why serotonin is important for learning to adapt to such changes.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Probing protein flexibility reveals a mechanism for selective promiscuity

    Nicolas A Pabon, Carlos J Camacho
    Conserved contacts on cognate ligands trigger an induced fit pathway that confers selective promiscuity to PD-1, a flexible regulatory protein and promising anticancer target.
    1. Ecology
    2. Neuroscience

    Range-dependent flexibility in the acoustic field of view of echolocating porpoises (Phocoena phocoena)

    Danuta M Wisniewska, John M Ratcliffe ... Peter T Madsen
    Harbor porpoises dynamically control biosonar field of view as they track and capture prey, focusing the beam through deformations to the melon.
    1. Cell Biology
    2. Computational and Systems Biology

    On the flexibility of the cellular amination network in E coli

    Helena Schulz-Mirbach, Alexandra Müller ... Steffen N Lindner
    The amination network for the distribution of assimilated ammonium throughout metabolism is defined by promiscuous transaminases, allowing a high flexibility of the network that supported engineering novel connections and even alternative ammonium assimilation entry points.
    1. Neuroscience

    The role of oxytocin in delay of gratification and flexibility in non-social decision making

    Georgia Eleni Kapetaniou, Matthias A Reinhard ... Alexander Soutschek
    Oxytocin was found to significantly improve non-social decision making in a healthy sample, suggesting a domain-general function of the hormone, in contrast to its previously hypothesized social domain specificity.
    1. Neuroscience

    A novel method for estimating properties of attentional oscillators reveals an age-related decline in flexibility

    Ece Kaya, Sonja A Kotz, Molly J Henry
    Individual performance in rhythm perception and production is maximized within a range of domain-specific rates and is adversely affected by temporal context, and this effect is amplified with age.
    1. Structural Biology and Molecular Biophysics

    Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

    Stefan A Zukin, Matthew R Marunde ... Avinash B Patel
    The core of histone acetyltransferase complex, NuA4, flexibly tethers various histone recognition modules, including the HAT module which is capable of binding nucleosomes marked by H3K4me3 and H3 acetylation.
    1. Neuroscience

    Rapid, automated, and experimenter-free touchscreen testing reveals reciprocal interactions between cognitive flexibility and activity-based anorexia in female rats

    Kaixin Huang, Laura K Milton ... Claire J Foldi
    An automated touchscreen cognitive testing system for rats reduces the length of training required to learn tasks, making it possible to assess cognitive profiles in adolescent animals to more appropriately capture cognitive deficits in adolescent pathologies, such as anorexia nervosa.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Super Spy variants implicate flexibility in chaperone action

    Shu Quan, Lili Wang ... James CA Bardwell
    Lab-evolved 'super Spy' chaperones show enhanced flexibility, which allows them to bind to and stabilize proteins more effectively than natural chaperones.
    1. Neuroscience

    fruitless tunes functional flexibility of courtship circuitry during development

    Jie Chen, Sihui Jin ... Yufeng Pan
    The courtship master gene fruitless tunes functional flexibility of courtship circuitry during development instead of switching on its function as conventionally viewed.

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