The well-studied Kv1.2 potassium ion channel is observed in a variety of states and conditions, to understand mechanisms of ion permeation, gating and block.
Julia A Hotinger, Ian W Campbell ... Matthew K Waldor
Microbial lineage tracing during murine systemic infection with Salmonella uncovered the bottlenecks that restrict colonization and the hidden routes of interorgan dissemination that drive heterogeneity in infection outcomes.
Timo van Kerkoerle, Louise Pape ... Ghislaine Dehaene-Lambertz
Humans spontaneously reverse learned associations while macaque monkeys do not, providing a minimal test of a distinctive human capacity for symbolic representations.
A piece of first-surface mirror for side-view observation enables non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process.
M Julia Maristany, Anne Aguirre Gonzalez ... Jerelle A Joseph
Phase diagrams for 140 variants of prion-like low-complexity domains are computed to establish scaling laws that quantify the impact of amino acid mutations on the thermodynamic stability of condensates.
Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
xCas9's ability to recognise diverse DNA sequences stems from structural flexibility in the protospacer adjacent motif (PAM)-interacting cleft and adaptability to PAM-induced conformational changes, paving the way for advanced genome editing tools.
