Leveraging the X-LD method for estimating inter-chromosomal linkage disequilibrium in the human genome uncovers a universal extended LD pattern, consistent with observations in 1KG cohorts.
Alisha Schlichter, Margaret M Kasten ... Bradley R Cairns
A SWI/SNF-family chromatin remodeling subcomplex from yeast is identified (RSC1) that is specialized to slide nucleosomes residing on DNA sequences that confer partial nucleosome unwrapping, with assistance from accessory factors.
Debashree Chatterjee, Richard B Cooley ... Holger Sondermann
Structure-function analyses reveal the mechanistic underpinnings of inside-out transmembrane signaling that controls periplasmic proteolysis, and thereby biofilm formation, in bacteria and may be relevant in the context of other signaling proteins with similar control elements.
A landmark-based cross-modality alignment method robust to variation in landmark sets is applied to annotate an EM time series of Caenorhabditis elegans embryonic development as a community resource.
Perception is proposed to be a dynamic motor-sensory closed-loop process in which information flows through the environment and the brain in continuous loops, converging towards steady-state percepts.
Klara Katarina Nordén, Chad M Eliason, Mary Caswell Stoddard
Despite having different shapes and structures, the melanosomes (melanin-packed organelles) in bird feathers often produce thin melanin layers, giving rise to brilliant iridescence.
Jerome C Nwachukwu, Sathish Srinivasan ... Kendall W Nettles
Anti-inflammatory effects of resveratrol are mediated by the estrogen receptor to coordinate a complex array of transcriptional coregulators, suggesting that estrogenic effects must be considered in the complex polypharmacology of resveratrol.
Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.
