268 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Transport mechanism of P4 ATPase phosphatidylcholine flippases

    Lin Bai et al.
    A detailed molecular mechanism on lipid flipping from outside leaflet to the inside leaflet of the eukaryotic plasma membrane bilayer.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

    Christoph Heier et al.
    An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
    1. Structural Biology and Molecular Biophysics

    The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Simon Mysling et al.
    Intravascular triglyceride hydrolysis by lipoprotein lipase is crucial for delivering lipid nutrients to vital tissues, such as the heart, skeletal muscle, and adipose tissue.
    1. Structural Biology and Molecular Biophysics

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Cancer Biology

    LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer

    Pang-Kuo Lo et al.
    LIPG, a lipoprotein lipase, executes its oncogenic function in human basal-like triple-negative breast cancer through its functional involvement in DTX3L-ISG15 signaling, an interferon-related pathway that regulates protein functionality by ISGylation.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati et al.
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Biochemistry and Chemical Biology

    GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

    Xuchen Hu et al.
    The expression of the lipoprotein lipase (LPL) transporter GPIHBP1 in glioma capillaries promotes the LPL-mediated processing of triglyceride-rich lipoproteins, thereby providing lipid nutrients for glioma cells.
    1. Cell Biology

    The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi

    Olga Martzoukou et al.
    In filamentous fungi the AP-2 complex, which in mammals is an adaptor of clathrin-mediated endocytosis, is recruited to specific clathrin-independent apical endocytosis necessary for proper lipid maintenance and polar growth.
    1. Stem Cells and Regenerative Medicine

    ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

    Wieneke Dijk et al.
    During sustained cold exposure, lipid fuel is specifically directed towards brown adipose tissue, but not white adipose tissue, via cold-induced regulation of Angiopoietin-like 4 (ANGPTL4).
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss

    Oliver W Bayfield et al.
    Structure of the portal protein of a thermostable virus, determined in its capsid-bound state, reveals a molecular mechanism that prevents DNA slippage during genome packaging.

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