79 results found
    1. Neuroscience

    Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice

    Srikanta Chowdhury et al.
    Subtraction analysis using novel Orexin-Flp mice isolated physiological importance of orexin peptides.
    1. Neuroscience

    Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure

    Aitak Farzi et al.
    CART exerts differential metabolic effects in response to activation of neurons of the Arc, where CART suppresses energy expenditure, while it enforces the reward characteristics of the LHA.
    1. Chromosomes and Gene Expression

    Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

    Carl A Morrow et al.
    The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.
    1. Developmental Biology
    2. Neuroscience

    The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections

    Xiaojun Xie et al.
    The organization of layered/laminated axon projections in specific regions of the fruitfly central brain is regulated by short-range repulsive guidance and is critical for local inhibitory circuit formation and function.
    1. Neuroscience

    A robust activity marking system for exploring active neuronal ensembles

    Andreas T Sørensen et al.
    A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.
    1. Structural Biology and Molecular Biophysics
    2. Human Biology and Medicine

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Cell Biology

    Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

    Anna P Baron et al.
    Chemical inhibition of Bub1 shows that the catalytic activity is not required for normal mitotic progression, but it makes chromosome segregation and cell proliferation more sensitive to the effects of the anti-cancer drug Paclitaxel.
    1. Microbiology and Infectious Disease

    Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

    Yael Artzy-Randrup et al.
    Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.
    1. Cell Biology
    2. Human Biology and Medicine

    Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

    Xin Rong et al.
    The enzyme Lpcat3 plays a unique role in the incorporation of arachidonic acid into membranes, which is required for the production of lipoproteins.
    1. Cell Biology

    Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

    Risheng Ye et al.
    Under insulinopenic conditions, the hormone adiponectin is essential for lipid uptake specifically in subcutaneous white adipose tissue, and is sufficient to ameliorate islet lipotoxicity.

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