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    1. Epidemiology and Global Health

    Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy

    Maia A Rabaa et al.
    In large vaccine trials conducted in dengue-endemic Asia and Latin America, the CYD-TDV tetravalent dengue vaccine shows limited variation in intra-serotype efficacy in the target population for vaccination (>9 years).
    1. Developmental Biology
    2. Neuroscience

    Regulation of retinal axon growth by secreted Vax1 homeodomain protein

    Namsuk Kim et al.
    Secreted Vax1 homeodomain protein supports the development of optic chiasm by directly acting at the retinal ganglion cell axon.
    1. Neuroscience

    Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex

    Sarah Ruediger, Massimo Scanziani
    Neural pathways from mammalian visual cortex to ancestral brain structures control learning speed and performance of a simple detection task.
    1. Plant Biology

    Regulation of shoot meristem shape by photoperiodic signaling and phytohormones during floral induction of Arabidopsis

    Atsuko Kinoshita et al.
    The shoot meristem becomes domed in shape during floral transition and this is controlled by flowering pathways and the phytohormone gibberellin causing increases in cell size and number.
    1. Medicine
    2. Neuroscience

    Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist

    Jesus Javier Ballesteros et al.
    Instant performance recovery is possible following general anesthesia-induced unconsciousness using antagonist, and the brain dynamics return abruptly to the awake state without intermediate recovery states.
    1. Neuroscience

    Non-selective inhibition of inappropriate motor-tendencies during response-conflict by a fronto-subthalamic mechanism

    Jan R Wessel et al.
    Action-selection under response-conflict is buttressed by an inhibitory control signal from the basal ganglia that non-selectively suppresses motor excitability.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synergy between RecBCD subunits is essential for efficient DNA unwinding

    Rani Zananiri et al.
    A new optical tweezers assay sheds light on the mechanism of cooperation and force generation by the subunits of RecBCD, critical for the repair of double strand breaks in bacteria.
    1. Cell Biology
    2. Developmental Biology

    Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

    Yfat Yahalom-Ronen et al.
    Compliant matrix provides a permissive micoenvironment for cardiomyocyte dedifferentiation, cell division and expansion, and thus may open a new avenue towards cardiac regeneration.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Resistome diversity in cattle and the environment decreases during beef production

    Noelle R Noyes et al.
    Interventions in feedlots and abattoirs place selective pressure on the beef cattle resistome, which differentially impacts the public health risk of antimicrobial resistance from beef production sources.
    1. Stem Cells and Regenerative Medicine

    Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila

    Pauline Spéder, Andrea H Brand
    Cross talk between neural stem cells and their glial niche enables the niche to adapt to the evolving needs of the stem cells throughout development.