3,896 results found
    1. Developmental Biology

    Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation

    Rieko Asai, Vivek N Prakash ... Takashi Mikawa
    At the onset of gastrulation, primitive streak morphogenesis that requires mitosis along the embryo midline, persists even with a disrupted bilateral cell flow.
    1. Physics of Living Systems

    The younger flagellum sets the beat for Chlamydomonas reinhardtii

    Da Wei, Greta Quaranta ... Daniel SW Tam
    External hydrodynamic forcing on each flagellum of Chlamydomonas reinhardtii reveals a leader-follower relation between the two flagella in the synchronous beating.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

    Charles E MacKay, Miranda Floen ... Jonathan H Jaggar
    Flow stimulates PC-1/PC-2 clusters in the plasma membrane of endothelial cells, leading to Ca2+ influx, NOS, SK channel, and IK channel activation, vasodilation, and a reduction in blood pressure.
    1. Developmental Biology

    Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

    Mamoru Ishii, Tomoko Tateya ... Tsuyoshi Hirashima
    Live-cell imaging and mathematical modeling reveal the physical basis of collective cell migration underlying spiral cochlear duct formation during murine inner ear development.
    1. Physics of Living Systems

    Mapping spatial patterns to energetic benefits in groups of flow-coupled swimmers

    Sina Heydari, Haotian Hang, Eva Kanso
    Fish swimming in groups can either conserve or expend energy during collective movement, depending on their spatial position within the school.
    1. Neuroscience

    Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network

    Qinlin Yu, Minhui Ouyang ... Hao Huang
    Unprecedented 4D spatiotemporal infant regional cerebral blood flow framework and region-specific physiology–function coupling across infancy were elucidated, highlighting strong physiology–function coupling specifically at the default-mode network to meet extraneuronal metabolic demand for network emergence.
    1. Physics of Living Systems

    Learning developmental mode dynamics from single-cell trajectories

    Nicolas Romeo, Alasdair Hastewell ... Jörn Dunkel
    A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.
    1. Physics of Living Systems

    Strong confinement of active microalgae leads to inversion of vortex flow and enhanced mixing

    Debasmita Mondal, Ameya G Prabhune ... Prerna Sharma
    Coupling between cell motility and strong confinement alters the force generators that cause flow fields to change their handedness and lead to enhanced mixing.
    1. Neuroscience

    Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease

    Osman Shabir, Ben Pendry ... Jason Berwick
    Mice modelling atherosclerosis show neurovascular breakdown in the cortex compared to healthy controls, and inducing atherosclerosis in mice modelling Alzheimer's disease increases the number of amyloid plaques in the hippocampus.
    1. Physics of Living Systems
    2. Cell Biology

    Cortical flow aligns actin filaments to form a furrow

    Anne-Cecile Reymann, Fabio Staniscia ... Stephan W Grill
    Compressing the actomyosin network by cortical flow causes filaments to align and form a constricting ring.

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