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    1. Cell Biology
    2. Immunology and Inflammation

    Galectin-9 regulates the threshold of B cell activation and autoimmunity

    Logan K Smith, Kareem Fawaz, Bebhinn Treanor
    Galectin-9-deficient mice develop spontaneous autoimmunity, driven by a decreased threshold of B cell activation and enhanced auto-antigen delivery to the spleen by increased B1a-derived autoantibodies.
    1. Immunology and Inflammation

    Circulating T cell-monocyte complexes are markers of immune perturbations

    Julie G Burel, Mikhail Pomaznoy ... Bjoern Peters
    Human blood contains T cell-monocyte complexes which are not technical artefacts but reflect true in vivo immune cell interactions.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

    Rajdeep Banerjee, Thomas J Meyer ... David D Roberts
    Increased extramedullary erythropoiesis in spleen compensates for the elevated turnover of red blood cells in mice lacking CD47, but extramedullary erythropoiesis is suppressed in mice lacking the CD47 ligand thrombospondin-1.
    1. Immunology and Inflammation

    Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

    Ana CG Salina, Douglas dos-Santos ... Larissa D Cunha
    Internalization of apoptotic SARS-CoV-2 infected cells leads to proinflammatory macrophage activation and reduction in macrophage capacity to perform further efferocytosis.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch

    Hélène Duplus-Bottin, Martin Spichty ... Gaël Yvert
    A single protein catalyzes site-specific DNA recombination upon blue-light illumination.
    1. Developmental Biology

    Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

    Shawn A Hallett, Yuki Matsushita ... Noriaki Ono
    Slow-cycling chondrocytes are maintained in a Wnt-inhibitory environment within the resting zone, unraveling a novel mechanism regulating maintenance and differentiation of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells of the postnatal growth plate.
    1. Immunology and Inflammation

    Illuminating T cell-dendritic cell interactions in vivo by FlAsHing antigens

    Munir Akkaya, Jafar Al Souz ... Billur Akkaya
    Novel antigen-targeting probes, featuring a cysteine-rich tag emitting fluorescence, offer unprecedented insight into antigen-specific immune responses.
    1. Microbiology and Infectious Disease

    A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

    Anamaria Babosan, David Skurnik ... Thomas Guillard
    A mechanism whereby aminoglycosides-mediated SOS induction in Escherichia coli also promote high-level fluoroquinolone resistance.
    1. Immunology and Inflammation

    Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

    Marianna Santopaolo, Michaela Gregorova ... Laura Rivino
    Prolonged CD4+ and CD8+ T-cell activation and long COVID symptoms at 3 months post hospitlization independently associate with severe COVID-19, and ongoing T-cell activation does not affect the generation and maintenance of memory T-cell and antibody responses to SARS-CoV-2.

  10. Core strengths: an interview with Diana Ordonez

    Of all the tools that Diana Ordonez used to study populations of immune cells during her PhD and postdoc research, flow cytometry was the most important. Now she uses her experience and skills to advise and support other researchers as a Flow Cytometrist at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.
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