1,767 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria

    Joseph Robert Piechura et al.
    Cyanobacteria cope with both predictable day/night changes and natural fluctuations in light during the day by adjusting the expression dynamics of circadian-clock-controlled genes via a network of transcriptional regulators.
    1. Neuroscience

    Cross-synaptic synchrony and transmission of signal and noise across the mouse retina

    William N Grimes et al.
    Cells within the retina synchronize transmitter release across their output synapses in the dark, reducing the impact of noise generated at these synapses and allowing light-dependent signals to be transmitted with minimal added synaptic noise.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A simple regulatory architecture allows learning the statistical structure of a changing environment

    Stefan Landmann et al.
    Minimal modifications of common regulatory circuits can allow bacteria to learn from the past to better predict the future, on a physiological, rather than evolutionary, timescale.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Biophysical clocks face a trade-off between internal and external noise resistance

    Weerapat Pittayakanchit et al.
    Molecular clocks that are robust to external fluctuations are vulnerable to internal fluctuations and vice versa.
    1. Ecology
    2. Physics of Living Systems

    Microbial consortia at steady supply

    Thibaud Taillefumier et al.
    In a consumer-resource model obeying the physical requirement of flux conservation, metabolic competition between microbes yields consortia of cell types that collectively resist invasion via optimal use of resources.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Phenotypic states become increasingly sensitive to perturbations near a bifurcation in a synthetic gene network

    Kevin Axelrod et al.
    Perturbations in the extracellular environment drive transitions from a highly stable memory state to an alternative phenotype in microorganisms.
    1. Neuroscience

    The impact of bilateral ongoing activity on evoked responses in mouse cortex

    Daisuke Shimaoka et al.
    Spontaneous bilateral fluctuations add with evoked cortical activity and explain much of the variability in sensory responses.
    1. Computational and Systems Biology

    Phenotypic diversity and temporal variability in a bacterial signaling network revealed by single-cell FRET

    Johannes M Keegstra et al.
    Noise in a signaling network comprising thousands of molecules shapes diversity across cell populations and generates giant temporal fluctuations at the single-cell level.
    1. Computational and Systems Biology
    2. Developmental Biology

    Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

    Benedetta Ubezio et al.
    Increasing levels of the growth factor Vegfa disrupt blood vessel branching morphogenesis and drive diameter increase by synchronizing Notch signalling fluctuations between endothelial cells.
    1. Cell Biology

    The quantitative architecture of centromeric chromatin

    Dani L Bodor et al.
    The number of CENP-A molecules at human centromeres helps to explain how this structure is built and epigenetically inherited.

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