7,296 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Daily electrical activity in the master circadian clock of a diurnal mammal

    Beatriz Bano-Otalora, Matthew J Moye ... Mino DC Belle
    Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Identification of putative enhancer-like elements predicts regulatory networks active in planarian adult stem cells

    Jakke Neiro, Divya Sridhar ... Aziz Aboobaker
    Predicted gene regulatory networks active in planarians adult stem cells provide testable hypotheses about the control of pluripotency and differentiation in animals.
    1. Neuroscience

    One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

    Austin D Hocker, Sarah A Beyeler ... Adrianne G Huxtable
    A single neonatal inflammatory event induces long-term impairments in two forms of adult respiratory motor plasticity, an important aspect of the control of breathing for compensation after injury or disease.
    1. Immunology and Inflammation
    2. Medicine

    Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

    Dongjin Jeong, Hye Sung Kim ... Doo Hyun Chung
    Soluble Fas ligand interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor 5, exacerbating arthritis in a Fas-independent manner.
    1. Cell Biology
    2. Computational and Systems Biology

    Multi-omic analysis of bat versus human fibroblasts reveals altered central metabolism

    N Suhas Jagannathan, Javier Yu Peng Koh ... Lisa Tucker-Kellogg
    To investigate why bats are long-lived and cancer-resistant, multi-omic data from bat and human cells was analyzed using computational flux modeling, suggesting dysregulation of succinate-fumarate dynamics and an ischemic-like basal metabolism in bat cells.
    1. Neuroscience

    A role for descending auditory cortical projections in songbird vocal learning

    Yael Mandelblat-Cerf, Liora Las ... Michale S Fee
    Midbrain dopaminergic neurons and a cortex-like structure called the arcopallium form part of a circuit that enables young songbirds to compare their own song with a template stored in memory, and use any discrepancies to improve their performance.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Dynamic Na+/H+ exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca2+-dependent NHE1 activation

    Lise M Sjøgaard-Frich, Andreas Prestel ... Stine Falsig Pedersen
    NHE1-CaM complexes of multiple stoichiometries regulate cellular Ca2+-dependent NHE1 activity and can contribute to NHE1 dimerization, the latter shown by the NMR structure of CaM linking two NHE1 cytosolic tails.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

    Jinmi Choi, Kseniia Lysakovskaia ... Patrick Cramer
    Temporal changes in genome-wide enhancer transcription activity during a transdifferentiation event reveal additive and synergistic enhancer cooperation.
    1. Neuroscience

    FSHβ links photoperiodic signaling to seasonal reproduction in Japanese quail

    Gaurav Majumdar, Timothy A Liddle ... Tyler Stevenson
    Molecular analyses reveal the neuroendocrine control of seasonal life-history transitions in birds.
    1. Biochemistry and Chemical Biology

    Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

    Brent W Anderson, Kuanqing Liu ... Jue D Wang
    The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically altered through evolution of enzyme oligomerization.

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