691 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A family of fluoride-specific ion channels with dual-topology architecture

    Randy B Stockbridge et al.
    Efflux of xenobiotic fluoride from microorganisms occurs through a novel family of ion channels with stringent selectivity for fluoride ion and dual-topology molecular architecture.
    1. Structural Biology and Molecular Biophysics

    Molecular determinants of permeation in a fluoride-specific ion channel

    Nicholas B Last et al.
    The ion-transport pathway of an unconventional bacterial fluoride channel is mapped out through combined crystallographic and functional experiments.
    1. Structural Biology and Molecular Biophysics

    Mechanistic signs of double-barreled structure in a fluoride ion channel

    Nicholas B Last et al.
    Combining crystal structures with single-pore analysis of Fluc-family fluoride channel mutants demonstrates that Fluc channels have two separate fluoride ion permeation pathways within the channel complex.
    1. Developmental Biology
    2. Evolutionary Biology

    Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer

    Iryna Kozmikova, Zbynek Kozmik
    Wnt/beta-catenin signaling is essential for the specification of dorsal cell fate in amphioxus, suggesting a common evolutionary origin for the formation of the dorsal organizer in chordates.
    1. Developmental Biology
    2. Evolutionary Biology

    Limb Development: A lesson in homology

    Nikola-Michael Prpic
    The same genes and signaling pathways control the formation of limbs in vertebrates, arthropods and cuttlefish.
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  1. Meta-Research: How significant are the public dimensions of faculty work in review, promotion and tenure documents?

    Juan P Alperin et al.
    An analysis of review, promotion and tenure documents from 129 US and Canadian universities suggests institutions could better fulfill their public missions by changing how they incentivize the public dimensions of faculty work.
    1. Medicine
    2. Immunology and Inflammation

    Sepsis: Modelling survival

    Teresa A Zimmers, Leonidas G Koniaris
    A new mouse model of sepsis can reproduce the long-term muscle weakness seen in patients who survive this life-threatening illness.
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    1. Ecology
    Deer mouse illustration

    The Natural History of Model Organisms: Peromyscus mice as a model for studying natural variation

    Nicole L Bedford, Hopi E Hoekstra
    The deer mouse (Peromyscus) has emerged as a model system for studying many aspects of biology, supported by extensive historical knowledge of its fascinating and varied natural history.
    1. Ecology

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.

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