29 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure

    Duy Pham Thanh et al.
    A fluoroquinolone resistant variant of Salmonella Typhi has emerged that is likely to be widespread in the Indian subcontinent; therefore fluoroquinolones should not be recommended for empirical typhoid fever therapy in this setting.
    1. Microbiology and Infectious Disease

    High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

    Landry Blanc et al.
    Penetration of the fluoroquinolones in tuberculosis lesions is heterogeneous even in fully cellular areas, is driven by macrophage content and decreases as the distance from lesion outer rim increases.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure

    Stephen Baker et al.
    The major evolutionary routes to drug resistance in Salmonella Typhi are associated with fitness benefits, not fitness costs, implying that prudent antimicrobial use will have no effect as a public health intervention in controlling typhoid fever.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

    James E Gomez et al.
    Mutations in several components of a bacterial ribosome are shown to broadly decrease antibiotic and stress sensitivity, and readily accessible reversion mutations allow these ribosomal mutations to serve as stepping stones to high level antibiotic resistance.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones

    Martin Wilkinson et al.
    Building on previous work (Wilkinson et al, 2016), it is shown that inhibition of RecBCD-induced DNA break repair can be used as a co-antibacterial strategy with quinolones.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary pathways to antibiotic resistance are dependent upon environmental structure and bacterial lifestyle

    Alfonso Santos-Lopez et al.
    Bacteria growing in biofilms evolve antimicrobial resistance via different pathways and generate greater genetic diversity than well-mixed populations, selecting fitter but less resistant genotypes.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The distribution of antibiotic use and its association with antibiotic resistance

    Scott W Olesen et al.
    Population-level antibiotic resistance correlates with the breadth of antibiotic use, that is, the proportion of people taking an antibiotic, better than with intensity of use the amount of use among users.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antibiotic Resistance: Genomics against gonorrhoea

    Nicholas Medland
    Surveillance strategies based on whole genome sequencing could help with the early identification and detection of new forms of drug-resistant gonorrhoea.
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    1. Ecology
    2. Microbiology and Infectious Disease

    Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards

    Julie Teresa Shapiro et al.
    Patterns of antibiotic use and the connectivity between wards are independently associated with the incidence of antimicrobial-resistant infections in hospital networks.

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