446 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

    Samina Shaheen et al.
    The combination of molecular imaging, genetic and pharmacological approaches revealed that BCR signaling and PKCβ-dependent activation of focal adhesion kinase (FAK) is required for B cell mechanosensing.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

    Benjamin P Bouchet et al.
    Interactions between talin1 and a cortical scaffolding protein KANK1 control microtubule stabilization in the vicinity of focal adhesions.
    1. Cell Biology

    Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol

    Jan-Erik Hoffmann et al.
    In the cytosol, the proteins constituting cell-matrix adhesion sites form multi-protein building blocks which enter and leave these sites unaltered, thereby contributing to their rapid and correct self-assembly.
    1. Cell Biology

    The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells

    Anjali Teckchandani, Jonathan A Cooper
    A ubiquitin E3 ligase localizes to focal adhesions at the front of migrating human cells where it regulates cytoskeletal dynamics by targeting a focal adhesion protein.
    1. Cell Biology

    A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions

    Stephan A Eisler et al.
    The small GTPase Rho connects GPCR signaling with PKD activity at TGN membranes and consequently anterograde trafficking to focal adhesions.
    1. Cell Biology

    Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

    Joanna P Rys et al.
    Cells control the spatial organization and signaling of TGFβ receptors at focal adhesions via a mechanically regulated mechanism to integrate biochemical and physical cues.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Mechanobiology: A brighter force gauge for cells

    Victor Pui-Yan Ma, Khalid Salaita
    An improved biosensor sheds new light on tension within proteins.
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Focal Adhesions: Bridging the gap

    Sarah K Armitage, Sergey V Plotnikov
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

    Xuchen Hu et al.
    Macrophages release 30-nm vesicular particles enriched in accessible cholesterol during cellular locomotion, a discovery that is likely relevant to cholesterol disposal by these cells.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Tunable molecular tension sensors reveal extension-based control of vinculin loading

    Andrew S LaCroix et al.
    A quantitative understanding of molecular tension sensor function enables the production of unique sensors with desired mechanical properties as well as the ability to distinguish between protein force and protein deformation in mechanosensitive processes.

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