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    1. Neuroscience

    optoPAD, a closed-loop optogenetics system to study the circuit basis of feeding behaviors

    José-Maria Moreira et al.
    The optoPAD system combines real-time behavioral analysis with optogenetic manipulations to study how animals adapt to dynamic gustatory environments and to identify the circuit basis of feeding.
    1. Neuroscience

    Closed-loop optogenetic activation of peripheral or central neurons modulates feeding in freely moving Drosophila

    Pierre-Yves Musso et al.
    The Sip-Triggered Optogenetic Behavior Enclosure (STROBE) produces robust behaviors via activation of peripheral or central neurons in the fly, and mimics key features of feeding driven by chemical taste ligands.
    1. Neuroscience

    Neuronal variability and tuning are balanced to optimize naturalistic self-motion coding in primate vestibular pathways

    Diana E Mitchell et al.
    A match between neuronal variability and tuning enables optimized coding of natural self-motion in early vestibular pathways.
    1. Neuroscience

    Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in a Drosophila feeding connectome

    Anton Miroschnikow et al.
    A parallel neuronal network architecture ensures control of basic feeding reflex circuits via integration of crossmodal sensory information to filter multiple biological events and enhance meaningful behavioral choice.
    1. Neuroscience

    Dynamic representation of 3D auditory space in the midbrain of the free-flying echolocating bat

    Ninad B Kothari et al.
    Neurons in the midbrain superior colliculus of free-flying echolocating bats represent 3D sensory space, and the depth tuning of single neurons is modulated by an animal's active sonar inspection of physical objects in its environment.
    1. Computational and Systems Biology

    Neural oscillations as a signature of efficient coding in the presence of synaptic delays

    Matthew Chalk et al.
    Neural oscillations are a necessary consequence of efficient coding of sensory signals by a spiking neural network, limited by synaptic delays and noise.
    1. Cancer Biology
    2. Computational and Systems Biology

    Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate

    Malene Juul et al.
    A new statistical approach identifies non-coding regulatory regions of genes as driver candidates with recurrent mutations across cancer samples that associate with gene expression, patient survival or mutational phenotype.
    1. Neuroscience

    Phase-amplitude coupling supports phase coding in human ECoG

    Andrew J Watrous et al.
    Electrocorticography (ECoG) reveals that phase-amplitude coupling relates to phase-dependent coding in the human brain.
    1. Neuroscience

    The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

    Xiang-Chun Ju et al.
    Introducing a hominoid-specific gene into mice induces cortical folding.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural evidence for Scc4-dependent localization of cohesin loading

    Stephen M Hinshaw et al.
    Cohesin loading at centromeres depends on a conserved surface cluster of amino-acid residues on the cohesin loading protein, Scc4.