87 results found
    1. Ecology
    2. Microbiology and Infectious Disease

    Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing

    Heidi A Arjes et al.
    Novel high-throughput co-culture assays reveal how the spatial structure of colony biofilms provides opportunities for nutrient and matrix sharing and may drive the evolution of cooperative behaviors.
    1. Developmental Biology

    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

    Qiuyu Guo et al.
    β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

    Jürgen Tuvikene et al.
    An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
    1. Immunology and Inflammation

    The kinase PDK1 is critical for promoting T follicular helper cell differentiation

    Zhen Sun et al.
    PDK1 serves as a critical role for intrinsically promoting T follicular helper cell differentiation and effector functions via controlling expression level of TCF1.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

    Christoph Heier et al.
    An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
    1. Immunology and Inflammation

    Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

    Guillem Angulo et al.
    ICOSL-dependent T-cell co-stimulation contributes to the host defense against herpesvirus infections, and accordingly, these pathogens have developed immune evasion mechanisms to interrupt the ICOSL:ICOS signaling pathway.
    1. Structural Biology and Molecular Biophysics

    Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

    Deivanayagabarathy Vinayagam et al.
    Cryo-EM structures reveal how the canonical TRPC4 cation channel is regulated by calmodulin, and how it is modulated by pyridazinone-based inhibitors.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

    Lukas Ded et al.
    Fertilizing mouse spermatozoa, characterized by intact CatSper channels, lack of protein tyrosine phosphorylation, and reacted acrosomes, in the female reproductive tract provide molecular insight into sperm selection for successful fertilization.
    1. Developmental Biology
    2. Neuroscience

    Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus

    Jessica E Biddinger et al.
    Leptin acts cell autonomously on brainstem neurons that express GLP-1 to suppress development of excitatory viscerosensory inputs to the hypothalamus.
    1. Computational and Systems Biology
    2. Developmental Biology

    Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity

    Tarun Kumar et al.
    Regulatory networks of genes controlling different aspects of insect reproduction have been identified by a systems-level analysis of quantitative phenotypic information obtained from the loss of individual cell signaling genes.

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