34 results found
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Cleavage activates Dispatched for Sonic Hedgehog ligand release

    Daniel P Stewart et al.
    Dispatched cleavage, mediated by Furin, regulates Dispatched membrane trafficking and release of Sonic Hedgehog ligand.
    1. Immunology

    Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity

    Marianne Burbage et al.
    Intersectin2 deficiency is associated with impaired humoral responses to viral infection and B-cell-intrisic defects in germinal centre formation, resulting from the reduced ability of intersectin2-KO B cells to establish cognate interactions with helper T cells.
    1. Developmental Biology and Stem Cells

    The zinc-finger transcription factor Hindsight regulates ovulation competency of Drosophila follicles

    Lylah D Deady et al.
    Hindsight/RREB-1 plays a conserved role in follicle maturation and ovulation by sequential upregulation of matrix metalloproteinase and adrenergic receptor in follicle cells.
    1. Human Biology and Medicine

    A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency

    Baptiste Fouquet et al.
    Bilallelic mutations of FANCM, a DNA-damage response gene whose heterozygous mutations predispose to breast cancer, are involved in a familial case of Primary Ovarian Insufficiency establishing a link between infertility and cancer.
    1. Developmental Biology and Stem Cells

    A gonad-expressed opsin mediates light-induced spawning in the jellyfish Clytia

    Gonzalo Quiroga Artigas et al.
    Gamete release in the jellyfish Clytia is mediated by an opsin photopigment expressed in neurosecretory cells of the gonad ectoderm, which release an oocyte maturation hormone in response to light.
    1. Developmental Biology and Stem Cells

    Essential role for SUN5 in anchoring sperm head to the tail

    Yongliang Shang et al.
    SUN5 is essential for the tight junction between sperm head and the head-tail coupling apparatus, and is the main cause of human acephalic spermatozoa syndrome.
    1. Developmental Biology and Stem Cells
    2. Immunology

    Modulation of occluding junctions alters the hematopoietic niche to trigger immune activation

    Rohan J Khadilkar et al.
    Occluding-junctions form a permeability barrier around the hematopoietic niche in Drosophila that controls the production of immune cells in response to infection by shaping the signalling micro-environment produced by the niche.
    1. Microbiology and Infectious Disease

    A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

    Sunil Kumar Dogga et al.
    An aspartyl protease is essential for the lytic cycle of Toxoplasma gondii and is involved in the maturation of proteins critical for invasion and egress, and it can be targeted selectively with an ethylamine scaffold based peptidomimetic inhibitor.
    1. Cell Biology
    2. Neuroscience

    The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

    Jie Gao et al.
    Control of lipoprotein receptor protein levels at synapses by the E3 ubiquitin ligase IDOL is shown to be important for the plasticity of neuronal dendrites in vitro and learning and memory in mice.
    1. Developmental Biology and Stem Cells

    Stem Cells: A Collection of Articles

    Curated by Fiona Watt et al.
    eLife editors present a collection of stem cell research published in the journal.

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