7,267 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Oxyntomodulin regulates resetting of the liver circadian clock by food

    Dominic Landgraf et al.
    The gut-released peptide oxyntomodulin mediates the alignment of liver clock gene and metabolic transcript rhythms with the timing of food intake by postprandial induction of hepatic Per gene expression.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Optical estimation of absolute membrane potential using fluorescence lifetime imaging

    Julia R Lazzari-Dean et al.
    Fluorescence lifetime imaging microscopy, paired with fluorescent, voltage-sensitive dyes, provides a method for measuring and quantifying membrane potentials of living cells.
  1. Meta-Research: Questionable research practices may have little effect on replicability

    Rolf Ulrich, Jeff Miller
    Although questionable research practices inflate false positive rates, they have little effect on replicability because they also increase power.
    1. Ecology

    Cyclic bouts of extreme bradycardia counteract the high metabolism of frugivorous bats

    M Teague O'Mara et al.
    Novel heart rate strategies that minimize energy expenditure during the day are necessary to cope with high energy nocturnal lifestyles of tent-making bats.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte et al.
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of diverse membrane target recognitions by ankyrins

    Chao Wang et al.
    The 24 ankyrin repeats of ankyrin proteins form an extended solenoid that provides an extremely conserved groove for binding to numerous targets via combinatorial usage of multiple weak interaction sites.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity

    James R Partridge et al.
    Cytosolic and organellar Hsp90s from higher eukaryotes have evolved a variable, and environmentally responsive N-terminal extension to regulate their activity.
    1. Stem Cells and Regenerative Medicine

    A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

    Henrik Renner et al.
    Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
    1. Neuroscience

    CaImAn an open source tool for scalable calcium imaging data analysis

    Andrea Giovannucci et al.
    CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
    1. Ecology

    A fitness trade-off between seasons causes multigenerational cycles in phenotype and population size

    Gustavo S Betini et al.
    Seasonal variation in resources causes opposing episodes of selection on body size, which interact with density dependence to influence population dynamics.

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