1,347 results found
    1. Neuroscience

    Sex-specific resilience of neocortex to food restriction

    Zahid Padamsey, Danai Katsanevaki ... Nathalie L Rochefort
    Multi-scale analysis of mouse visual cortex reveals a sex-specific difference in response to long-term food restriction, with males being more impacted than females.
    1. Cancer Biology
    2. Genetics and Genomics

    FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction

    Avantika Gupta, Hugo Stocker
    Transcriptomic and genetic analyses of FoxO target genes reveal a key function of ER-associated protein degradation in growth regulation of Tsc1-deficient tissues.
    1. Chromosomes and Gene Expression

    Serotonin signaling mediates protein valuation and aging

    Jennifer Ro, Gloria Pak ... Scott D Pletcher
    Serotonin modulates diet-dependent lifespan in flies.
    1. Neuroscience

    Olfactory connectivity mediates sleep-dependent food choices in humans

    Surabhi Bhutani, James D Howard ... Thorsten Kahnt
    Sleep deprivation enhances energy-dense food choices and encoding of olfactory information in the human brain.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection

    Bryan L Gitschlag, Ann T Tate, Maulik R Patel
    Food supply and nutrient stress tolerance coordinately shape the multilevel selection dynamics of a mitochondrial cheater by promoting cheater persistence at both within-host and between-host levels of selection.
    1. Neuroscience

    Endogenous opioids in the nucleus accumbens promote approach to high-fat food in the absence of caloric need

    Kevin Caref, Saleem M Nicola
    Activation of mu-opioid receptors in the nucleus accumbens by their endogenous ligands promotes consumption of high-fat food in sated but not hungry rats, via enhancement of a neural signal that promotes cued approach behavior.
    1. Evolutionary Biology
    2. Medicine

    A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females

    Brooke Zanco, Christen K Mirth ... Matthew DW Piper
    Micronutrients, not macronutrients, regulate lifespan.
    1. Neuroscience

    Rapid, automated, and experimenter-free touchscreen testing reveals reciprocal interactions between cognitive flexibility and activity-based anorexia in female rats

    Kaixin Huang, Laura K Milton ... Claire J Foldi
    An automated touchscreen cognitive testing system for rats reduces the length of training required to learn tasks, making it possible to assess cognitive profiles in adolescent animals to more appropriately capture cognitive deficits in adolescent pathologies, such as anorexia nervosa.
    1. Neuroscience

    A gene-expression-based neural code for food abundance that modulates lifespan

    Eugeni V Entchev, Dhaval S Patel ... QueeLim Ch'ng
    TGFβ and serotonin signaling in a neural circuit encodes food availability; these signals regulate the dynamic range and variability on the circuit to impact coding accuracy and lifespan responses.
    1. Neuroscience

    Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area

    Marcella M Cline, Barbara Juarez ... Larry S Zweifel
    Genetic analysis of Ntn1 in adult mouse midbrain neurons reveals its function in maintaining excitatory synapses, loss of Ntn1 function in inhibitory neurons is significantly detrimental to mesolimbic system function.

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