Pim J Huis in 't Veld, Vladimir A Volkov ... Marileen Dogterom
Binding of two macromolecular complexes allows kinetochores to capture force produced by the depolymerising ends of microtubules, allowing chromosomes to be transmitted from a mother cell to its two daughters.
David R Shook, Eric M Kasprowicz ... Raymond Keller
Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.
Patrick Bakenecker, Tobias Weingarten ... Brent Raiteri
Increasing muscle length, rather than increasing stretch amplitude, contributes more to residual force enhancement during submaximal voluntary contractions of the human quadriceps.
Breane G Budaitis, Shashank Jariwala ... Kristen J Verhey
Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.
After shaking hands with a stranger, human volunteers often subliminally bring their hand to their nose and sniff it, possibly to collect important olfactory information.
Sebastian Carsten Johannes Helle, Qian Feng ... Benoît Kornmann
Mechanically stimulating mitochondria causes them to divide via the recruitment of the mitochondrial fission machinery to the mechanically strained site, showing that intracellular organelles can be mechanoresponsive.
Arul Subramanian, Lauren Fallon Kanzaki ... Thomas Friedrich Schilling
Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.
Artur Ruppel, Dennis Wörthmüller ... Martial Balland
Combining micropatterning, traction force microscopy, and optogenetics, it is shown that epithelial cells actively respond to mechanical signals from neighboring cells.
George Vaisey, Priyam Banerjee ... Roderick MacKinnon
Super-resolution microscopy and single particle tracking analysis of Piezo1 in red blood cells demonstrate its ability to sense membrane curvature, consistent with a force-through-membrane mechanism of channel mechanosensation in these cells.