3,695 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

    Pim J Huis in 't Veld, Vladimir A Volkov ... Marileen Dogterom
    Binding of two macromolecular complexes allows kinetochores to capture force produced by the depolymerising ends of microtubules, allowing chromosomes to be transmitted from a mother cell to its two daughters.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

    David R Shook, Eric M Kasprowicz ... Raymond Keller
    Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.
    1. Physics of Living Systems

    Residual force enhancement is affected more by quadriceps muscle length than stretch amplitude

    Patrick Bakenecker, Tobias Weingarten ... Brent Raiteri
    Increasing muscle length, rather than increasing stretch amplitude, contributes more to residual force enhancement during submaximal voluntary contractions of the human quadriceps.
    1. Neuroscience

    Fatigue induces long-lasting detrimental changes in motor-skill learning

    Meret Branscheidt, Panagiotis Kassavetis ... Pablo Celnik
    A series of experiments shows how muscle fatigue impairs motor-skill learning on subsequent practice days beyond its effects on task execution.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

    Breane G Budaitis, Shashank Jariwala ... Kristen J Verhey
    Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.
    1. Neuroscience

    A social chemosignaling function for human handshaking

    Idan Frumin, Ofer Perl ... Noam Sobel
    After shaking hands with a stranger, human volunteers often subliminally bring their hand to their nose and sniff it, possibly to collect important olfactory information.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mechanical force induces mitochondrial fission

    Sebastian Carsten Johannes Helle, Qian Feng ... Benoît Kornmann
    Mechanically stimulating mitochondria causes them to divide via the recruitment of the mitochondrial fission machinery to the mechanically strained site, showing that intracellular organelles can be mechanoresponsive.
    1. Cell Biology
    2. Developmental Biology

    Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling

    Arul Subramanian, Lauren Fallon Kanzaki ... Thomas Friedrich Schilling
    Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.
    1. Cell Biology
    2. Physics of Living Systems

    Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

    Artur Ruppel, Dennis Wörthmüller ... Martial Balland
    Combining micropatterning, traction force microscopy, and optogenetics, it is shown that epithelial cells actively respond to mechanical signals from neighboring cells.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Piezo1 as a force-through-membrane sensor in red blood cells

    George Vaisey, Priyam Banerjee ... Roderick MacKinnon
    Super-resolution microscopy and single particle tracking analysis of Piezo1 in red blood cells demonstrate its ability to sense membrane curvature, consistent with a force-through-membrane mechanism of channel mechanosensation in these cells.

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