Binding of two macromolecular complexes allows kinetochores to capture force produced by the depolymerising ends of microtubules, allowing chromosomes to be transmitted from a mother cell to its two daughters.
LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
The range of footfall patterns seen in walking amphibians, reptiles and mammals, including hippopotamus, horse and (inverted) sloth, are consistent with simple principles of mechanical work minimization.
Emergence of hematopoietic stem cells from an aortic component is a unique phenomenon of cell extrusion, with no equivalent in cell biology, and which is adapted to environmental constraints exerted by endothelial cells and hemodynamics forces.
The genomic architecture of allopatric species is a mosaic of many conserved genes and a few adaptive ones, reflecting balance between conservation of ancestral functions and evolution of new features.
Perturbation of mechanical force at muscle attachments and its effects on tendon morphogenesis provides insights into the mechanisms underlying cellular responses to tensional force and resulting extracellular matrix production.