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    1. Physics of Living Systems
    2. Developmental Biology

    Unified quantitative characterization of epithelial tissue development

    Boris Guirao, Stéphane U Rigaud ... Yohanns Bellaïche
    A new approach measures the respective participations of elementary cell behaviors – such as cell division, intercalation, shape change and death – in the shaping of animal tissues.
    1. Computational and Systems Biology
    2. Neuroscience

    Interrogating theoretical models of neural computation with emergent property inference

    Sean R Bittner, Agostina Palmigiano ... John Cunningham
    Emergent property inference, a novel machine learning methodology, learns distributions of neural circuit model parameters that produce computational properties and provides novel scientific insight through the quantification of the rich parametric structure it captures.
    1. Neuroscience

    Stretching the skin immediately enhances perceived stiffness and gradually enhances the predictive control of grip force

    Mor Farajian, Raz Leib ... Ilana Nisky
    Elucidating the contribution of augmented artificial skin-stretch stimulation to the fingertips to the immediate illusion of a higher stiffness and to an increased predictive grip force control.
    1. Physics of Living Systems

    3D single cell migration driven by temporal correlation between oscillating force dipoles

    Amélie Luise Godeau, Marco Leoni ... Daniel Riveline
    A phase shift between local contractions drives 3D cell motility in experiments and in model or how a finite area in the dipole-quadrupole space explains cell motion with zero total force.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar, Litao Xie ... Rajan Sah
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    T cell stiffness is enhanced upon formation of immunological synapse

    Philipp Jung, Xiangda Zhou ... Bin Qu
    Upon activation of T cell receptors at the contact site, T cells were substantially stiffened at the cell body as well as at the lamellipodia, which is mediated by Ca2+.
    1. Structural Biology and Molecular Biophysics

    Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion

    Esteban Dodero-Rojas, Jose N Onuchic, Paul Charles Whitford
    SARS-CoV-2 entry mechanism through membrane fusion is regulated by the spike protein glycosylation state.
    1. Neuroscience

    Drosophila mechanical nociceptors preferentially sense localized poking

    Zhen Liu, Meng-Hua Wu ... Xin Liang
    A fly larval mechanical nociceptor develops dedicated neuronal mechanisms to support its sensory preference in detecting localized poking forces, and this sensory feature well supports the physiological function of the nociceptor in sensing the physical attack of its natural enemy.
    1. Physics of Living Systems

    Shared behavioral mechanisms underlie C. elegans aggregation and swarming

    Siyu Serena Ding, Linus J Schumacher ... André EX Brown
    Two seemingly distinct behaviors in social C. elegans worms, namely aggregating into groups and swarming over food, are driven by the same underlying mechanisms.
    1. Neuroscience

    A size principle for recruitment of Drosophila leg motor neurons

    Anthony W Azevedo, Evyn S Dickinson ... John C Tuthill
    Motor neurons controlling the leg of the fruit fly exhibit a gradient of physiological and functional properties that correlate with the order in which they fire during behavior.