2,157 results found
    1. Cell Biology
    2. Physics of Living Systems

    Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

    Artur Ruppel, Dennis Wörthmüller ... Martial Balland
    Combining micropatterning, traction force microscopy, and optogenetics, it is shown that epithelial cells actively respond to mechanical signals from neighboring cells.
    1. Neuroscience

    Drosophila mechanical nociceptors preferentially sense localized poking

    Zhen Liu, Meng-Hua Wu ... Xin Liang
    A fly larval mechanical nociceptor develops dedicated neuronal mechanisms to support its sensory preference in detecting localized poking forces, and this sensory feature well supports the physiological function of the nociceptor in sensing the physical attack of its natural enemy.
    1. Microbiology and Infectious Disease

    Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

    Mart M Lamers, Anna Z Mykytyn ... Bart L Haagmans
    Cell culture adaptation of SARS-CoV-2 is prevented on human airway cells with an active serine protease-mediated entry pathway, allowing the production of genetically stable virus stocks for laboratory experiments.
    1. Medicine
    2. Neuroscience

    The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle

    Xueyong Wang, Murad Nawaz ... Mark M Rich
    Detailed studies of excitation contraction coupling allowed determination of quantitative relationships between resting potential, generation of action potentials, conduction of action potentials, and generation of Ca2+ transients in individual mouse skeletal muscle fibers.
    1. Cell Biology

    ATP activation of peritubular cells drives testicular sperm transport

    David Fleck, Lina Kenzler ... Marc Spehr
    Purinergic signaling controls mammalian sperm transport.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Working strokes produced by curling protofilaments at disassembling microtubule tips can be biochemically tuned and vary with species

    Lucas E Murray, Haein Kim ... Charles L Asbury
    Laser trap measurements show that mechanical work output from curling protofilaments is enhanced by adding magnesium, and that yeast microtubules generate larger and more energetic working strokes than bovine microtubules.
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical design principles of a mitotic spindle

    Jonathan J Ward, Hélio Roque ... François Nédélec
    Precise control of microtubule architecture greatly increases the force that the spindle can exert on chromosomes.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Chemotactic smoothing of collective migration

    Tapomoy Bhattacharjee, Daniel B Amchin ... Sujit Sankar Datta
    Studies of bacterial chemotaxis reveal how limitations in single-cell sensing of stimuli influence large-scale population morphology.
    1. Physics of Living Systems

    Residual force enhancement is affected more by quadriceps muscle length than stretch amplitude

    Patrick Bakenecker, Tobias Weingarten ... Brent Raiteri
    Increasing muscle length, rather than increasing stretch amplitude, contributes more to residual force enhancement during submaximal voluntary contractions of the human quadriceps.
    1. Computational and Systems Biology
    2. Neuroscience

    Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

    Timon Merk, Victoria Peterson ... Wolf-Julian Neumann
    Advanced machine learning based brain signal decoding of grip-force as a proxy for movement vigor shows Parkinson's disease related performance reduction, suggestive of a loss of cortical vigor encoding in the absence of dopamine.

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