1,081 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen, Anders S Hansen ... Xavier Darzacq
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Computational and Systems Biology
    2. Neuroscience

    A stochastic neuronal model predicts random search behaviors at multiple spatial scales in C. elegans

    William M Roberts, Steven B Augustine ... Shawn R Lockery
    A stochastic model of locomotory control in C. elegans based on an extensive new set of tracking data can explain and predict effects of ablations and mutations on behavior.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin-4 KIF21B is a potent microtubule pausing factor

    Wilhelmina E van Riel, Ankit Rai ... Anna Akhmanova
    Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.
    1. Neuroscience

    Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error

    Jessica N Goedhoop, Bastijn JG van den Boom ... Ingo Willuhn
    The extracellular concentration of dopamine in the nucleus accumbens core is progressively diminished by white noise, an underutilized, easy-to-titrate aversive stimulus, but is unaffected by white-noise intensity, context valence, and associated probabilistic contingencies.
    1. Neuroscience

    Global organization of neuronal activity only requires unstructured local connectivity

    David Dahmen, Moritz Layer ... Moritz Helias
    Short-ranged and random connectivity are sufficient to explain complex, long-range activity patterns observed in macaque motor cortex that are, moreover, flexibly adaptable to behavior.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Juxtaposition of heterozygous and homozygous regions causes reciprocal crossover remodelling via interference during Arabidopsis meiosis

    Piotr A Ziolkowski, Luke E Berchowitz ... Ian R Henderson
    Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.
    1. Neuroscience

    Long ascending propriospinal neurons provide flexible, context-specific control of interlimb coordination

    Amanda M Pocratsky, Courtney T Shepard ... David SK Magnuson
    Conditional silencing of long ascending propriospinal neurons disrupts interlimb coordination of the fore and hindlimb pairs, but in a highly context-specific manner.
    1. Neuroscience

    Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions

    Michael J Goard, Gerald N Pho ... Mriganka Sur
    Visual, parietal, and frontal motor cortices play distinct and necessary roles in mapping sensory features to future motor action.
    1. Cell Biology

    Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts

    Charlotte Guyomar, Clément Bousquet ... Denis Chrétien
    Tubulin engages unique lateral interactions without longitudinal ones during microtubule polymerization, leaving holes of a few subunits size potentially at the origin of tubulin exchange within their shaft.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake

    Marc A Schureck, Joseph E Darling ... Sanjay A Desai
    A high-resolution structure reveals how the RhopH complex traffics within Plasmodium-infected human erythrocytes to serve divergent, essential functions.

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