362 results found
    1. Structural Biology and Molecular Biophysics

    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl/H+ transport cycle

    Tanmay S Chavan et al.
    Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.
    1. Neuroscience

    Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice

    Sheila Hoffmann-Conaway et al.
    The presynaptic scaffolding protein Bassoon is involved in regulating neurotransmitter release by controlling synaptic vesicle pool size and vesicular protein turnover through increased ubiquitination and Parkin-dependent autophagy.
    1. Developmental Biology
    2. Neuroscience

    Expansion microscopy of C. elegans

    Chih-Chieh (Jay) Yu et al.
    Fixed, intact animals of C. elegans can be physically expanded with high isotropy, to enable super-resolved imaging of general proteins and nucleic acids throughout the organism, on conventional microscopes.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

    Maeva Dupont et al.
    Type-I interferon enriched microenvironment generated by Mycobacterium tuberculosis induces the Siglec-1 receptor expression in human macrophages, including on tunneling nanotubes, and contributes to the exacerbation of cell-to-cell transfer of HIV-1.
    1. Computational and Systems Biology

    A molecular view on the escape of lipoplexed DNA from the endosome

    Bart MH Bruininks et al.
    The molecular insight in lipoplex transfection mechanisms helps in the development of efficient and affordable gene delivery systems.
    1. Cell Biology
    2. Developmental Biology

    Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy

    Claudia Prahst et al.
    Improved 3D and 4D imaging of neurovascular processes across scales reveals new insights into eye disease mouse models and shows retinal vessels are significantly distorted using standard flat-mount confocal imaging.
    1. Neuroscience

    Primate homologs of mouse cortico-striatal circuits

    Joshua Henk Balsters et al.
    Connectivity fingerprint matching bridges the gap between mouse and primate neuroanatomy, addressing crucial questions surrounding brain evolution that likely impact translation across species.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

    Andrea Ruiz-Velasco et al.
    Targeting mir128-3p could prevent cardiac insulin resistance in the non-infarcted myocardium and limit cardiac injury after myocardial infarction, delaying the development of heart failure.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

    Kevin Michalski et al.
    The structure of a pannexin 1 uncovers the extracellular loops of pannexin 1 as important structural motifs for ion selectivity and channel inhibition.
    1. Epidemiology and Global Health

    The hazards of smoking and the benefits of cessation: a critical summation of the epidemiological evidence in high-income countries

    Prabhat Jha
    Cumulatively, from 1950 to 2015, smoking-related disease has been the biggest cause of premature death in high-income countries, with elevated risks of smoking continuing well into the 21st century.

Refine your results by:

Type
Research categories