663 results found
    1. Structural Biology and Molecular Biophysics

    Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

    Siyang Sun, Ye Xiang ... Michael G Rossmann
    Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
    1. Physics of Living Systems

    Sequence-dependent base pair stepping dynamics in XPD helicase unwinding

    Zhi Qi, Robert A Pugh ... Yann R Chemla
    The ability of an enzyme called XPD helicase to unwind the double helix is influenced by the DNA sequence and the availability of energy.
    1. Cell Biology

    Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

    Ling Luo, Hironori Uehara ... Balamurali K Ambati
    The eye produces a protein that inhibits the growth of blood vessels in the deep retina, which includes the photoreceptor layer, and disruption of this process can lead to blindness.
    1. Structural Biology and Molecular Biophysics

    Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

    Manchuta Dangkulwanich, Toyotaka Ishibashi ... Carlos J Bustamante
    Quantification of all the major on- and off-pathway kinetic parameters in the transcription elongation cycle reveals that RNA polymerase II translocates slowly in a linear, non-branched Brownian ratchet mechanism.
    1. Microbiology and Infectious Disease

    The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria

    Sara C Di Rienzi, Itai Sharon ... Ruth E Ley
    Melainabacteria, a candidate phylum related to Cyanobacteria, has been identified in gut and sediment samples by genomic analysis.
    1. Biochemistry and Chemical Biology

    Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion

    Michael Zick, Christopher Stroupe ... William T Wickner
    Lipids with a propensity to form nonbilayer structures must be present for the last step of membrane fusion to take place.
    1. Ecology

    Climate-mediated cooperation promotes niche expansion in burying beetles

    Syuan-Jyun Sun, Dustin R Rubenstein ... Sheng-Feng Shen
    Cooperation enables burying beetles to outcompete flies and adapt to a wider range of temperatures as thermal generalists.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection

    Don B Gammon, Sophie Duraffour ... Craig C Mello
    Novel virus-host systems yield insights into how Lepidopterans (moths and butterflies) combat RNA virus infection and reveal that poxvirus A51R proteins can suppress the host's immune system and stabilize microtubules in host cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

    Maria Vera, Bibhusita Pani ... Evgeny Nudler
    Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Mapping the zoonotic niche of Ebola virus disease in Africa

    David M Pigott, Nick Golding ... Simon I Hay
    Understanding where future Ebola virus outbreaks may start and the changing nature of the populations living in these places is of critical importance in helping to prepare for future outbreaks.

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